ENSG00000168907


Homo sapiens

Features
Gene ID: ENSG00000168907
  
Biological name :PLA2G4F
  
Synonyms : phospholipase A2 group IVF / PLA2G4F / Q68DD2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q15.1
Gene start: 42139034
Gene end: 42156636
  
Corresponding Affymetrix probe sets: 235958_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454330
Ensembl peptide - ENSP00000455037
Ensembl peptide - ENSP00000455513
Ensembl peptide - ENSP00000456697
Ensembl peptide - ENSP00000290497
Ensembl peptide - ENSP00000380442
NCBI entrez gene - 255189     See in Manteia.
RefSeq - NM_213600
RefSeq Peptide - NP_998765
swissprot - Q68DD2
swissprot - H3BMD0
swissprot - H3BNW4
swissprot - H3BPX7
swissprot - H3BSG9
swissprot - H7BXJ8
Ensembl - ENSG00000168907
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g4f.1ENSDARG00000056535Danio rerio
 pla2g4f.2ENSDARG00000070953Danio rerio
 PLA2G4FENSGALG00000043591Gallus gallus
 Q50L41ENSMUSG00000046971Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q86XP0 / PLA2G4D / phospholipase A2 group IVDENSG0000015933740
Q3MJ16 / PLA2G4E / phospholipase A2 group IVEENSG0000018808939
JMJD7-PLA2G4B / JMJD7-PLA2G4B readthroughENSG0000016897039
P0C869 / PLA2G4B / phospholipase A2 group IVBENSG0000024370838
P47712 / PLA2G4A / phospholipase A2 group IVAENSG0000011671127
Q9UP65 / PLA2G4C / phospholipase A2 group IVCENSG0000010549918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002642  Lysophospholipase, catalytic domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0015908 fatty acid transport IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0036148 phosphatidylglycerol acyl-chain remodeling TAS
 biological_processGO:0036149 phosphatidylinositol acyl-chain remodeling TAS
 biological_processGO:0036150 phosphatidylserine acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling TAS
 biological_processGO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0071236 cellular response to antibiotic IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 molecular_functionGO:0004620 phospholipase activity IEA
 molecular_functionGO:0004622 lysophospholipase activity IEA
 molecular_functionGO:0004623 phospholipase A2 activity TAS
 molecular_functionGO:0008970 phosphatidylcholine 1-acylhydrolase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047498 calcium-dependent phospholipase A2 activity IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Hydrolysis of LPC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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