ENSMUSG00000046971


Mus musculus

Features
Gene ID: ENSMUSG00000046971
  
Biological name :Pla2g4f
  
Synonyms : Cytosolic phospholipase A2 zeta / Pla2g4f / Q50L41
  
Possible biological names infered from orthology : phospholipase A2 group IVF / Q68DD2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 120299957
Gene end: 120314165
  
Corresponding Affymetrix probe sets: 10486448 (MoGene1.0st)   1455408_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062607
NCBI entrez gene - 271844     See in Manteia.
MGI - MGI:2685493
RefSeq - XM_006499652
RefSeq - NM_001024145
RefSeq - XM_006499650
RefSeq - XM_006499651
RefSeq - XM_006499649
RefSeq Peptide - NP_001019316
swissprot - Q50L41
Ensembl - ENSMUSG00000046971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g4f.1ENSDARG00000056535Danio rerio
 pla2g4f.2ENSDARG00000070953Danio rerio
 PLA2G4FENSGALG00000043591Gallus gallus
 Q68DD2ENSG00000168907Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm28042 / P0C869* / PLA2G4B* / JMJD7-PLA2G4B* / JMJD7-PLA2G4B readthrough* / phospholipase A2 group IVB*ENSMUSG0000003385238
Pla2g4b / P0C869* / JMJD7-PLA2G4B* / JMJD7-PLA2G4B readthrough* / phospholipase A2 group IVB*ENSMUSG0000009848837
Q50L43 / Pla2g4d / Cytosolic phospholipase A2 delta / Q86XP0* / phospholipase A2 group IVD*ENSMUSG0000007071937
Q50L42 / Pla2g4e / Cytosolic phospholipase A2 epsilon / Q3MJ16* / phospholipase A2 group IVE*ENSMUSG0000005021135
P47713 / Pla2g4a / phospholipase A2, group IVA (cytosolic, calcium-dependent) / P47712* / phospholipase A2 group IVA*ENSMUSG0000005622025
Q64GA5 / Pla2g4c / Cytosolic phospholipase A2 gamma / Q9UP65* / phospholipase A2 group IVC*ENSMUSG0000003384718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002642  Lysophospholipase, catalytic domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0015908 fatty acid transport IDA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0050482 arachidonic acid secretion IDA
 biological_processGO:0071236 cellular response to antibiotic IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0032587 ruffle membrane IDA
 molecular_functionGO:0004620 phospholipase activity IEA
 molecular_functionGO:0004622 lysophospholipase activity IDA
 molecular_functionGO:0004623 phospholipase A2 activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047498 calcium-dependent phospholipase A2 activity IDA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Hydrolysis of LPC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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