ENSMUSG00000056220


Mus musculus

Features
Gene ID: ENSMUSG00000056220
  
Biological name :Pla2g4a
  
Synonyms : P47713 / phospholipase A2, group IVA (cytosolic, calcium-dependent) / Pla2g4a
  
Possible biological names infered from orthology : P47712 / phospholipase A2 group IVA
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G1
Gene start: 149829618
Gene end: 149961290
  
Corresponding Affymetrix probe sets: 10358434 (MoGene1.0st)   1448558_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070868
Ensembl peptide - ENSMUSP00000107557
Ensembl peptide - ENSMUSP00000139851
NCBI entrez gene - 18783     See in Manteia.
MGI - MGI:1195256
RefSeq - NM_001305632
RefSeq - NM_008869
RefSeq Peptide - NP_001292561
RefSeq Peptide - NP_032895
swissprot - Q9DBX5
swissprot - P47713
swissprot - Q3UMQ1
swissprot - A0A087WPN8
Ensembl - ENSMUSG00000056220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g4aaENSDARG00000024546Danio rerio
 pla2g4abENSDARG00000017141Danio rerio
 P49147ENSGALG00000005065Gallus gallus
 P47712ENSG00000116711Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q50L43 / Pla2g4d / Cytosolic phospholipase A2 delta / Q86XP0* / phospholipase A2 group IVD*ENSMUSG0000007071929
Q50L42 / Pla2g4e / Cytosolic phospholipase A2 epsilon / Q3MJ16* / phospholipase A2 group IVE*ENSMUSG0000005021129
Q50L41 / Pla2g4f / Cytosolic phospholipase A2 zeta / Q68DD2* / phospholipase A2 group IVF*ENSMUSG0000004697129
Gm28042 / P0C869* / PLA2G4B* / JMJD7-PLA2G4B* / JMJD7-PLA2G4B readthrough* / phospholipase A2 group IVB*ENSMUSG0000003385227
Pla2g4b / P0C869* / JMJD7-PLA2G4B* / JMJD7-PLA2G4B readthrough* / phospholipase A2 group IVB*ENSMUSG0000009848826
Q64GA5 / Pla2g4c / Cytosolic phospholipase A2 gamma / Q9UP65* / phospholipase A2 group IVC*ENSMUSG0000003384718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002642  Lysophospholipase, catalytic domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0046456 icosanoid biosynthetic process IMP
 biological_processGO:0050482 arachidonic acid secretion IDA
 biological_processGO:0071236 cellular response to antibiotic IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004620 phospholipase activity IEA
 molecular_functionGO:0004622 lysophospholipase activity IEA
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047498 calcium-dependent phospholipase A2 activity ISO
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
phospho-PLA2 pathway
Acyl chain remodelling of PC
Acyl chain remodeling of CL
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Hydrolysis of LPC
Synthesis of PA
Arachidonic acid metabolism
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
COPI-independent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: ApcMin/Apc+,Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: B6.Cg-Pla2g4atm1Jvb ApcMin

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Pax6Sey-Dey/Pax6+
Genetic Background: involves: C3H/HeJ

Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4a+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0002872 polycythemia "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: ApcMin/Apc+,Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: B6.Cg-Pla2g4atm1Jvb ApcMin

 MP:0003033 abnormal pulmonary vascular resistance "deviation from the normal force opposing blood flow in the lung blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: B6.Cg-Pla2g4atm1Jvb ApcMin

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005462 abnormal mast cell morphology/development "anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: B6.Cg-Pla2g4atm1Jvb ApcMin

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008764 increased mast cell degranulation "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0008997 increased blood osmolality "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: B6.Cg-Pla2g4atm1Jvb ApcMin

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0010936 decreased airway resistance "reduced opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011452 decreased susceptibility to dopaminergic neuron neurotoxicity "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Pla2g4atm1Jvb/Pla2g4atm1Jvb
Genetic Background: involves: 129S4/SvJae

 MP:0012010 parturition failure "the process of labor and delivery in female animals does not initiate or complete" [MGI:csmith]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction






 

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