ENSGALG00000005065


Gallus gallus

Features
Gene ID: ENSGALG00000005065
  
Biological name :PLA2G4A
  
Synonyms : Cytosolic phospholipase A2 Phospholipase A2 Lysophospholipase / P49147 / PLA2G4A
  
Possible biological names infered from orthology : P47712 / P47713 / phospholipase A2 group IVA / phospholipase A2, group IVA (cytosolic, calcium-dependent)
  
Species: Gallus gallus
  
Chr. number: 8
Strand: -1
Band:
Gene start: 9797493
Gene end: 9862645
  
Corresponding Affymetrix probe sets: Gga.12245.1.S1_at (Chicken Array)   Gga.3723.1.S1_at (Chicken Array)   Gga.3723.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043575
Ensembl peptide - ENSGALP00000055774
Ensembl peptide - ENSGALP00000048642
Ensembl peptide - ENSGALP00000048216
Ensembl peptide - ENSGALP00000008107
NCBI entrez gene - 396394     See in Manteia.
RefSeq - XM_015290572
RefSeq - XM_015290566
RefSeq - XM_015290567
RefSeq - XM_015290568
RefSeq - XM_015290569
RefSeq - XM_015290570
RefSeq - XM_015290571
RefSeq - NM_205423
RefSeq - XM_015290563
RefSeq - XM_015290564
RefSeq - XM_015290565
RefSeq Peptide - NP_990754
swissprot - A0A1I7Q3Z2
swissprot - A0A1D5PS91
swissprot - A0A1D5P7F3
swissprot - A0A1D5NTC1
swissprot - P49147
Ensembl - ENSGALG00000005065
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g4aaENSDARG00000024546Danio rerio
 pla2g4abENSDARG00000017141Danio rerio
 P47712ENSG00000116711Homo sapiens
 P47713ENSMUSG00000056220Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLA2G4F / phospholipase A2 group IVF / Q50L41* / Q68DD2* / Cytosolic phospholipase A2 zeta *ENSGALG0000004359128
Q3MJ16* / Q50L42* / PLA2G4E* / phospholipase A2 group IVE* / Cytosolic phospholipase A2 epsilon *ENSGALG0000004340127
Q3MJ16* / Q50L42* / PLA2G4E* / phospholipase A2 group IVE* / Cytosolic phospholipase A2 epsilon *ENSGALG0000002045827
Q86XP0* / P0C869* / Q50L43* / PLA2G4D* / Gm28042* / PLA2G4B* / JMJD7-PLA2G4B* / JMJD7-PLA2G4B readthrough* / phospholipase A2 group IVB* / phospholipase A2 group IVD* / Cytosolic phospholip...ENSGALG0000000872725
Q3MJ16* / Q50L42* / PLA2G4E* / phospholipase A2 group IVE* / Cytosolic phospholipase A2 epsilon *ENSGALG0000004430725
Q3MJ16* / Q50L42* / PLA2G4E* / phospholipase A2 group IVE* / Cytosolic phospholipase A2 epsilon *ENSGALG0000004579625
Q3MJ16* / Q50L42* / PLA2G4E* / phospholipase A2 group IVE* / Cytosolic phospholipase A2 epsilon *ENSGALG0000002658421
Q3MJ16* / Q50L42* / PLA2G4E* / phospholipase A2 group IVE* / Cytosolic phospholipase A2 epsilon *ENSGALG0000002840220
Q3MJ16* / Q50L42* / PLA2G4E* / phospholipase A2 group IVE* / Cytosolic phospholipase A2 epsilon *ENSGALG0000002945416
ENSGALG000000451557


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002642  Lysophospholipase, catalytic domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0046456 icosanoid biosynthetic process IEA
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0071236 cellular response to antibiotic IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004620 phospholipase activity IEA
 molecular_functionGO:0004622 lysophospholipase activity IEA
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
phospho-PLA2 pathway
Acyl chain remodelling of PC
Acyl chain remodeling of CL
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Hydrolysis of LPC
Synthesis of PA
Arachidonic acid metabolism
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
COPI-independent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / reaction






 

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