ENSDARG00000017141


Danio rerio

Features
Gene ID: ENSDARG00000017141
  
Biological name :pla2g4ab
  
Synonyms : phospholipase A2, group IVAb (cytosolic, calcium-dependent) / pla2g4ab
  
Possible biological names infered from orthology : P47712 / P47713 / phospholipase A2 group IVA / phospholipase A2, group IVA (cytosolic, calcium-dependent) / PLA2G4A
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 34129465
Gene end: 34148190
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000130121
Ensembl peptide - ENSDARP00000024335
Ensembl peptide - ENSDARP00000119528
swissprot - A0A0R4ICC9
swissprot - F1Q5L4
swissprot - Q5RIP7
ZFIN ID - ZDB-GENE-041014-325
Ensembl - ENSDARG00000017141
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P49147ENSGALG00000005065Gallus gallus
 P47712ENSG00000116711Homo sapiens
 P47713ENSMUSG00000056220Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pla2g4aa / phospholipase A2, group IVAa (cytosolic, calcium-dependent) / P47713* / P47712* / PLA2G4A* / phospholipase A2 group IVA* / phospholipase A2, group IVA (cytosolic, calcium-dependent)*ENSDARG0000002454677
pla2g4f.2 / phospholipase A2, group IVF, tandem duplicate 2 / Q68DD2* / Q50L41* / PLA2G4F* / phospholipase A2 group IVF* / Cytosolic phospholipase A2 zeta *ENSDARG0000007095327
pla2g4f.1 / phospholipase A2, group IVF, tandem duplicate 1 / Q68DD2* / Q50L41* / PLA2G4F* / phospholipase A2 group IVF* / Cytosolic phospholipase A2 zeta *ENSDARG0000005653527
zgc:101699 / Q9UP65* / PLA2G4C* / phospholipase A2 group IVC*ENSDARG0000003335518
si:ch73-55i23.1 / Q9UP65* / PLA2G4C* / phospholipase A2 group IVC*ENSDARG0000004598218
si:ch73-55i23.1 / Q64GA5* / Q9UP65* / PLA2G4C* / phospholipase A2 group IVC* / Cytosolic phospholipase A2 gamma *ENSDARG0000004209018
LO018584.1 / Q9UP65* / PLA2G4C* / phospholipase A2 group IVC*ENSDARG0000010172117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002642  Lysophospholipase, catalytic domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IGI
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004620 phospholipase activity IDA
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
phospho-PLA2 pathway
Acyl chain remodelling of PC
Acyl chain remodeling of CL
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Hydrolysis of LPC
Synthesis of PA
Arachidonic acid metabolism
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
COPI-independent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000128 midbrain midbrain decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000028721 mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*  / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000000857 Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*  / reaction






 

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