ENSG00000188089


Homo sapiens

Features
Gene ID: ENSG00000188089
  
Biological name :PLA2G4E
  
Synonyms : phospholipase A2 group IVE / PLA2G4E / Q3MJ16
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q15.1
Gene start: 41981582
Gene end: 42051190
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000382434
NCBI entrez gene - 123745     See in Manteia.
RefSeq - NM_001206670
RefSeq - XM_011521237
RefSeq Peptide - NP_001193599
swissprot - Q3MJ16
Ensembl - ENSG00000188089
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000020458Gallus gallus
 ENSGALG00000028402Gallus gallus
 ENSGALG00000029454Gallus gallus
 ENSGALG00000026584Gallus gallus
 ENSGALG00000045796Gallus gallus
 ENSGALG00000044307Gallus gallus
 ENSGALG00000043401Gallus gallus
 Q50L42ENSMUSG00000050211Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q86XP0 / PLA2G4D / phospholipase A2 group IVDENSG0000015933742
JMJD7-PLA2G4B / JMJD7-PLA2G4B readthroughENSG0000016897041
P0C869 / PLA2G4B / phospholipase A2 group IVBENSG0000024370839
Q68DD2 / PLA2G4F / phospholipase A2 group IVFENSG0000016890738
P47712 / PLA2G4A / phospholipase A2 group IVAENSG0000011671126
Q9UP65 / PLA2G4C / phospholipase A2 group IVCENSG0000010549916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002642  Lysophospholipase, catalytic domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0036149 phosphatidylinositol acyl-chain remodeling TAS
 biological_processGO:0036150 phosphatidylserine acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling TAS
 biological_processGO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004620 phospholipase activity IEA
 molecular_functionGO:0004622 lysophospholipase activity TAS
 molecular_functionGO:0004623 phospholipase A2 activity TAS
 molecular_functionGO:0008970 phosphatidylcholine 1-acylhydrolase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Hydrolysis of LPC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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