ENSG00000243708


Homo sapiens

Features
Gene ID: ENSG00000243708
  
Biological name :PLA2G4B
  
Synonyms : P0C869 / phospholipase A2 group IVB / PLA2G4B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q15.1
Gene start: 41837775
Gene end: 41848147
  
Corresponding Affymetrix probe sets: 219095_at (Human Genome U133 Plus 2.0 Array)   60528_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000416610
Ensembl peptide - ENSP00000456919
Ensembl peptide - ENSP00000396045
NCBI entrez gene - 100137049     See in Manteia.
OMIM - 606088
RefSeq - NM_001114633
RefSeq Peptide - NP_001108105
swissprot - H3BSX5
swissprot - P0C869
Ensembl - ENSG00000243708
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000008727Gallus gallus
 Gm28042ENSMUSG00000033852Mus musculus
 Pla2g4bENSMUSG00000098488Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JMJD7-PLA2G4B / JMJD7-PLA2G4B readthroughENSG00000168970100
Q86XP0 / PLA2G4D / phospholipase A2 group IVDENSG0000015933751
Q3MJ16 / PLA2G4E / phospholipase A2 group IVEENSG0000018808944
Q68DD2 / PLA2G4F / phospholipase A2 group IVFENSG0000016890742
P47712 / PLA2G4A / phospholipase A2 group IVAENSG0000011671125
Q9UP65 / PLA2G4C / phospholipase A2 group IVCENSG0000010549918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002642  Lysophospholipase, catalytic domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process TAS
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0007567 parturition NAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019369 arachidonic acid metabolic process NAS
 biological_processGO:0019722 calcium-mediated signaling NAS
 biological_processGO:0036148 phosphatidylglycerol acyl-chain remodeling TAS
 biological_processGO:0036150 phosphatidylserine acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling TAS
 biological_processGO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0046475 glycerophospholipid catabolic process IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0004620 phospholipase activity IEA
 molecular_functionGO:0004622 lysophospholipase activity TAS
 molecular_functionGO:0004623 phospholipase A2 activity TAS
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005544 calcium-dependent phospholipid binding NAS
 molecular_functionGO:0008970 phosphatidylcholine 1-acylhydrolase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047498 calcium-dependent phospholipase A2 activity IDA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Hydrolysis of LPC
Synthesis of PA
XBP1(S) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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