ENSG00000066032


Homo sapiens

Features
Gene ID: ENSG00000066032
  
Biological name :CTNNA2
  
Synonyms : catenin alpha 2 / CTNNA2 / P26232
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p12
Gene start: 79185231
Gene end: 80648861
  
Corresponding Affymetrix probe sets: 205373_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387232
Ensembl peptide - ENSP00000387073
Ensembl peptide - ENSP00000400105
Ensembl peptide - ENSP00000486160
Ensembl peptide - ENSP00000444675
Ensembl peptide - ENSP00000441705
Ensembl peptide - ENSP00000419295
Ensembl peptide - ENSP00000418191
Ensembl peptide - ENSP00000341500
Ensembl peptide - ENSP00000355398
Ensembl peptide - ENSP00000384638
Ensembl peptide - ENSP00000386587
NCBI entrez gene - 1496     See in Manteia.
OMIM - 114025
RefSeq - XM_017003406
RefSeq - NM_001164883
RefSeq - NM_001282597
RefSeq - NM_001282598
RefSeq - NM_001282599
RefSeq - NM_001282600
RefSeq - NM_001320810
RefSeq - NM_004389
RefSeq - XM_011532555
RefSeq - XM_011532556
RefSeq - XM_011532557
RefSeq - XM_017003403
RefSeq - XM_017003404
RefSeq - XM_017003405
RefSeq Peptide - NP_001269527
RefSeq Peptide - NP_001269528
RefSeq Peptide - NP_001269529
RefSeq Peptide - NP_001307739
RefSeq Peptide - NP_004380
RefSeq Peptide - NP_001269526
RefSeq Peptide - NP_001158355
swissprot - P26232
swissprot - A0A0A0MRI5
swissprot - C9J144
swissprot - C9IZ88
swissprot - B9A010
swissprot - B8ZZE7
swissprot - A0A0A0MTJ6
swissprot - F6KRI5
Ensembl - ENSG00000066032
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B7ZC77ENSDARG00000024785Danio rerio
 ENSGALG00000015966Gallus gallus
 CTNNA2ENSGALG00000027853Gallus gallus
 Ctnna2ENSMUSG00000063063Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTNNA1 / P35221 / catenin alpha 1ENSG0000004411578
CTNNA3 / Q9UI47 / catenin alpha 3ENSG0000018323057
VCL / P18206 / vinculinENSG0000003540323
Q9UBT7 / CTNNAL1 / catenin alpha like 1ENSG0000011932621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000633  Vinculin, conserved site
 IPR001033  Alpha-catenin
 IPR006077  Vinculin/alpha-catenin
 IPR030046  Alpha N-catenin
 IPR030047  Alpha E-catenin
 IPR036723  Alpha-catenin/vinculin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007409 axonogenesis ISS
 biological_processGO:0021942 radial glia guided migration of Purkinje cell ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048813 dendrite morphogenesis ISS
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0051149 positive regulation of muscle cell differentiation TAS
 biological_processGO:0051823 regulation of synapse structural plasticity ISS
 biological_processGO:0060134 prepulse inhibition ISS
 biological_processGO:0090136 epithelial cell-cell adhesion IEA
 biological_processGO:0098609 cell-cell adhesion ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005912 adherens junction ISS
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188130 MAPK12 / P53778 / mitogen-activated protein kinase 12  / complex / reaction
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction / complex
 ENSG00000064309 CDON / Q4KMG0 / cell adhesion associated, oncogene regulated  / reaction / complex
 ENSG00000044115 CTNNA1 / P35221 / catenin alpha 1  / complex
 ENSG00000140299 BNIP2 / Q12982 / BCL2 interacting protein 2  / complex / reaction
 ENSG00000144857 BOC / Q9BWV1 / BOC cell adhesion associated, oncogene regulated  / reaction / complex
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000129910 CDH15 / P55291 / cadherin 15  / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000066032 CTNNA2 / P26232 / catenin alpha 2  / complex
 ENSG00000008294 SPAG9 / O60271 / sperm associated antigen 9  / complex / reaction
 ENSG00000170558 CDH2 / P19022 / cadherin 2  / complex
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex






 

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