ENSG00000088247


Homo sapiens

Features
Gene ID: ENSG00000088247
  
Biological name :KHSRP
  
Synonyms : KHSRP / KH-type splicing regulatory protein / Q92945
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 6413348
Gene end: 6424794
  
Corresponding Affymetrix probe sets: 204371_s_at (Human Genome U133 Plus 2.0 Array)   204372_s_at (Human Genome U133 Plus 2.0 Array)   212303_x_at (Human Genome U133 Plus 2.0 Array)   227555_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473254
Ensembl peptide - ENSP00000472347
Ensembl peptide - ENSP00000478033
Ensembl peptide - ENSP00000381216
Ensembl peptide - ENSP00000469431
Ensembl peptide - ENSP00000469804
Ensembl peptide - ENSP00000469830
Ensembl peptide - ENSP00000471146
Ensembl peptide - ENSP00000471262
Ensembl peptide - ENSP00000472328
NCBI entrez gene - 8570     See in Manteia.
OMIM - 603445
RefSeq - XM_017027410
RefSeq - NM_003685
RefSeq - XM_005259668
RefSeq - XM_011528395
RefSeq - XM_017027408
RefSeq - XM_017027409
RefSeq Peptide - NP_003676
swissprot - M0R263
swissprot - M0R3J3
swissprot - A0A087WTP3
swissprot - Q92945
swissprot - M0QXW7
swissprot - M0QYG1
swissprot - M0QYH3
swissprot - M0R0C6
swissprot - M0R251
swissprot - M0R0I5
Ensembl - ENSG00000088247
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 khsrpENSDARG00000026489Danio rerio
 KhsrpENSMUSG00000007670Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FUBP1 / Q96AE4 / far upstream element binding protein 1ENSG0000016261357
FUBP3 / Q96I24 / far upstream element binding protein 3ENSG0000010716443


Protein motifs (from Interpro)
Interpro ID Name
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR009019  K homology domain superfamily, prokaryotic type
 IPR015096  Far upstream element-binding protein, C-terminal
 IPR015946  K homology domain-like, alpha/beta
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000375 RNA splicing, via transesterification reactions TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing TAS
 biological_processGO:0006402 mRNA catabolic process IEA
 biological_processGO:0008380 RNA splicing TAS
 biological_processGO:0010586 miRNA metabolic process IMP
 biological_processGO:0043488 regulation of mRNA stability IDA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IDA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IDA
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IDA
 biological_processGO:0071345 cellular response to cytokine stimulus IMP
 biological_processGO:2000628 regulation of miRNA metabolic process IEA
 cellular_componentGO:0000178 exosome (RNase complex) NAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding IDA


Pathways (from Reactome)
Pathway description
ATF4 activates genes
KSRP (KHSRP) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000164924 YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  / complex
 ENSG00000140694 PARN / O95453 / poly(A)-specific ribonuclease  / reaction / complex
 ENSG00000172795 DCP2 / Q8IU60 / decapping mRNA 2  / reaction / complex






 

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