ENSG00000172795


Homo sapiens

Features
Gene ID: ENSG00000172795
  
Biological name :DCP2
  
Synonyms : DCP2 / decapping mRNA 2 / Q8IU60
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q22.2
Gene start: 112976702
Gene end: 113020970
  
Corresponding Affymetrix probe sets: 212919_at (Human Genome U133 Plus 2.0 Array)   235258_at (Human Genome U133 Plus 2.0 Array)   238779_at (Human Genome U133 Plus 2.0 Array)   244777_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427198
Ensembl peptide - ENSP00000373715
Ensembl peptide - ENSP00000424982
Ensembl peptide - ENSP00000425770
NCBI entrez gene - 167227     See in Manteia.
OMIM - 609844
RefSeq - XM_017009163
RefSeq - NM_001242377
RefSeq - NM_152624
RefSeq Peptide - NP_001229306
RefSeq Peptide - NP_689837
swissprot - D6RCL0
swissprot - H0Y9T5
swissprot - Q8IU60
Ensembl - ENSG00000172795
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dcp2ENSDARG00000104242Danio rerio
 DCP2ENSGALG00000000215Gallus gallus
 Dcp2ENSMUSG00000024472Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000086  NUDIX hydrolase domain
 IPR007722  mRNA decapping protein 2, Box A domain
 IPR015797  NUDIX hydrolase-like domain superfamily
 IPR020084  NUDIX hydrolase, conserved site
 IPR036189  mRNA decapping protein 2, Box A domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
 biological_processGO:0006402 mRNA catabolic process IEA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IMP
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
 biological_processGO:0071044 histone mRNA catabolic process IMP
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:1904872 regulation of telomerase RNA localization to Cajal body IMP
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016442 RISC complex IDA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004534 5"-3" exoribonuclease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016896 exoribonuclease activity, producing 5"-phosphomonoesters TAS
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050072 m7G(5")pppN diphosphatase activity IDA
 molecular_functionGO:0070034 telomerase RNA binding IC


Pathways (from Reactome)
Pathway description
ATF4 activates genes
mRNA decay by 5 to 3 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140694 PARN / O95453 / poly(A)-specific ribonuclease  / reaction / complex
 ENSG00000088247 KHSRP / Q92945 / KH-type splicing regulatory protein  / complex / reaction






 

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