ENSMUSG00000024472


Mus musculus

Features
Gene ID: ENSMUSG00000024472
  
Biological name :Dcp2
  
Synonyms : Dcp2 / m7GpppN-mRNA hydrolase / Q9CYC6
  
Possible biological names infered from orthology : decapping mRNA 2 / Q8IU60
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B3
Gene start: 44380502
Gene end: 44424969
  
Corresponding Affymetrix probe sets: 10455472 (MoGene1.0st)   1430150_at (Mouse Genome 430 2.0 Array)   1455070_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144010
Ensembl peptide - ENSMUSP00000025350
NCBI entrez gene - 70640     See in Manteia.
MGI - MGI:1917890
RefSeq - NM_027490
RefSeq Peptide - NP_081766
swissprot - A0A0J9YU54
swissprot - Q9CYC6
Ensembl - ENSMUSG00000024472
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dcp2ENSDARG00000104242Danio rerio
 DCP2ENSGALG00000000215Gallus gallus
 DCP2ENSG00000172795Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000086  NUDIX hydrolase domain
 IPR007722  mRNA decapping protein 2, Box A domain
 IPR015797  NUDIX hydrolase-like domain superfamily
 IPR020084  NUDIX hydrolase, conserved site
 IPR036189  mRNA decapping protein 2, Box A domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
 biological_processGO:0006402 mRNA catabolic process IEA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IEA
 biological_processGO:0071044 histone mRNA catabolic process IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:1904872 regulation of telomerase RNA localization to Cajal body IEA
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016442 RISC complex IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004534 5"-3" exoribonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050072 m7G(5")pppN diphosphatase activity IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 5 to 3 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tyrm3Btlr/Tyrm3Btlr
Genetic Background: involves: C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007670 Khsrp / Q3U0V1 / KH-type splicing regulatory protein / Q92945*  / reaction / complex
 ENSMUSG00000022685 Parn / poly(A)-specific ribonuclease / O95453*  / reaction / complex






 

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