ENSMUSG00000022685


Mus musculus

Features
Gene ID: ENSMUSG00000022685
  
Biological name :Parn
  
Synonyms : Parn / poly(A)-specific ribonuclease
  
Possible biological names infered from orthology : O95453
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 13537960
Gene end: 13668170
  
Corresponding Affymetrix probe sets: 10437778 (MoGene1.0st)   1425422_a_at (Mouse Genome 430 2.0 Array)   1437334_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055969
Ensembl peptide - ENSMUSP00000155076
Ensembl peptide - ENSMUSP00000155335
NCBI entrez gene - 74108     See in Manteia.
MGI - MGI:1921358
RefSeq - XM_017317145
RefSeq - NM_028761
RefSeq - XM_011246024
RefSeq - XM_017317144
RefSeq - XM_006522652
RefSeq - XM_011246023
RefSeq Peptide - NP_083037
swissprot - A0A0R4J0P6
Ensembl - ENSMUSG00000022685
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 parnENSDARG00000102634Danio rerio
 PARNENSGALG00000003091Gallus gallus
 PARNENSG00000140694Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B2RXZ1 / Pnldc1 / Poly(A)-specific ribonuclease PNLDC1 / Q8NA58* / PARN like, ribonuclease domain containing 1*ENSMUSG0000007346021


Protein motifs (from Interpro)
Interpro ID Name
 IPR001374  R3H domain
 IPR006941  Ribonuclease CAF1
 IPR012337  Ribonuclease H-like superfamily
 IPR014789  Poly(A)-specific ribonuclease, RNA-binding
 IPR034042  PARN, R3H domain
 IPR035979  RNA-binding domain superfamily
 IPR036397  Ribonuclease H superfamily
 IPR036867  R3H domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006402 mRNA catabolic process IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:0090669 telomerase RNA stabilization IEA
 biological_processGO:0110008 ncRNA deadenylation IEA
 biological_processGO:1904872 regulation of telomerase RNA localization to Cajal body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043169 cation binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
KSRP (KHSRP) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007670 Khsrp / Q3U0V1 / KH-type splicing regulatory protein / Q92945*  / reaction / complex
 ENSMUSG00000024472 Dcp2 / Q9CYC6 / m7GpppN-mRNA hydrolase / Q8IU60* / decapping mRNA 2*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr