ENSMUSG00000007670


Mus musculus

Features
Gene ID: ENSMUSG00000007670
  
Biological name :Khsrp
  
Synonyms : Khsrp / KH-type splicing regulatory protein / Q3U0V1
  
Possible biological names infered from orthology : Q92945
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: D
Gene start: 57021058
Gene end: 57031507
  
Corresponding Affymetrix probe sets: 10452228 (MoGene1.0st)   1428174_x_at (Mouse Genome 430 2.0 Array)   1436813_x_at (Mouse Genome 430 2.0 Array)   1452690_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007814
NCBI entrez gene - 16549     See in Manteia.
MGI - MGI:1336214
RefSeq - NM_010613
RefSeq Peptide - NP_034743
swissprot - Q3U0V1
Ensembl - ENSMUSG00000007670
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 khsrpENSDARG00000026489Danio rerio
 KHSRPENSG00000088247Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fubp1 / Q91WJ8 / Mus musculus far upstream element (FUSE) binding protein 1 (Fubp1), transcript variant 7, mRNA. / Q96AE4* / far upstream element binding protein 1*ENSMUSG0000002803454
Fubp3 / far upstream element binding protein 3 / Q96I24*ENSMUSG0000002684340


Protein motifs (from Interpro)
Interpro ID Name
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR015096  Far upstream element-binding protein, C-terminal
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006402 mRNA catabolic process IDA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010586 miRNA metabolic process IEA
 biological_processGO:0043488 regulation of mRNA stability IEA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IEA
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:2000628 regulation of miRNA metabolic process IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010494 cytoplasmic stress granule IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding IEA


Pathways (from Reactome)
Pathway description
KSRP (KHSRP) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008564 increased interferon-beta secretion "increase in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000022685 Parn / poly(A)-specific ribonuclease / O95453*  / reaction / complex
 ENSMUSG00000024472 Dcp2 / Q9CYC6 / m7GpppN-mRNA hydrolase / Q8IU60* / decapping mRNA 2*  / reaction / complex
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / reaction
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / reaction






 

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