ENSG00000164885


Homo sapiens

Features
Gene ID: ENSG00000164885
  
Biological name :CDK5
  
Synonyms : CDK5 / cyclin dependent kinase 5 / Q00535
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q36.1
Gene start: 151053812
Gene end: 151058530
  
Corresponding Affymetrix probe sets: 204247_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000297518
Ensembl peptide - ENSP00000419782
NCBI entrez gene - 1020     See in Manteia.
OMIM - 123831
RefSeq - NM_001164410
RefSeq - NM_004935
RefSeq Peptide - NP_001157882
RefSeq Peptide - NP_004926
swissprot - Q00535
swissprot - A0A090N7W4
swissprot - A0A0S2Z355
Ensembl - ENSG00000164885
  
Related genetic diseases (OMIM): 616342 - ?Lissencephaly 7 with cerebellar hypoplasia, 616342
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk5ENSDARG00000056683Danio rerio
 Cdk5ENSMUSG00000028969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK3 / Q00526 / cyclin dependent kinase 3ENSG0000025050661
CDK2 / P24941 / cyclin dependent kinase 2ENSG0000012337460
CDK1 / P06493 / cyclin dependent kinase 1ENSG0000017031256
CDK6 / Q00534 / cyclin dependent kinase 6ENSG0000010581046
CDK4 / P11802 / cyclin dependent kinase 4ENSG0000013544645
CDK10 / Q15131 / cyclin dependent kinase 10ENSG0000018532444
CDK11A / Q9UQ88 / cyclin dependent kinase 11AENSG0000000812842
CDK11B / cyclin dependent kinase 11BENSG0000024833342


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization TAS
 biological_processGO:0001764 neuron migration TAS
 biological_processGO:0001963 synaptic transmission, dopaminergic IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007416 synapse assembly TAS
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0008045 motor neuron axon guidance IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0014044 Schwann cell development IEA
 biological_processGO:0016079 synaptic vesicle exocytosis TAS
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0016310 phosphorylation IDA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISS
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISS
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021695 cerebellar cortex development IEA
 biological_processGO:0021697 cerebellar cortex formation IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021819 layer formation in cerebral cortex IEA
 biological_processGO:0021954 central nervous system neuron development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0022038 corpus callosum development IEA
 biological_processGO:0030182 neuron differentiation TAS
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030517 negative regulation of axon extension IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0031175 neuron projection development TAS
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031914 negative regulation of synaptic plasticity IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032801 receptor catabolic process IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0035418 protein localization to synapse IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042501 serine phosphorylation of STAT protein IEA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043113 receptor clustering IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISS
 biological_processGO:0045055 regulated exocytosis IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045861 negative regulation of proteolysis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0046826 negative regulation of protein export from nucleus IEA
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0048167 regulation of synaptic plasticity TAS
 biological_processGO:0048488 synaptic vesicle endocytosis TAS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048675 axon extension TAS
 biological_processGO:0048709 oligodendrocyte differentiation IDA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051402 neuron apoptotic process TAS
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic ISS
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis ISS
 biological_processGO:0070509 calcium ion import IEA
 biological_processGO:0071156 regulation of cell cycle arrest TAS
 biological_processGO:0090314 positive regulation of protein targeting to membrane IEA
 biological_processGO:1901215 negative regulation of neuron death IDA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1903076 regulation of protein localization to plasma membrane ISS
 biological_processGO:1903421 regulation of synaptic vesicle recycling NAS
 biological_processGO:1904646 cellular response to amyloid-beta ISS
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization TAS
 biological_processGO:2000273 positive regulation of signaling receptor activity IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0016533 protein kinase 5 complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0031594 neuromuscular junction ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity NAS
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0005176 ErbB-2 class receptor binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0016301 kinase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030549 acetylcholine receptor activator activity ISS
 molecular_functionGO:0043125 ErbB-3 class receptor binding ISS
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity ISS
 molecular_functionGO:0051879 Hsp90 protein binding IEA


Pathways (from Reactome)
Pathway description
DARPP-32 events
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models
Activated NTRK2 signals through CDK5
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000252 Microcephaly "Microcephaly is a neurodevelopmental disorder in which the circumference of the head is more than two standard deviations smaller than the age- and gender-dependent norm." [HPO:curators]
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 HP:0000293 Full cheeks 
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 HP:0000347 Mandibular hypoplasia "Underdevelopment of the mandible." [HPO:curators]
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 HP:0000470 Short neck 
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 HP:0001004 Lymphedema 
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 HP:0001007 Hirsutism "Abnormally increased hair growth." [HPO:curators]
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 HP:0001188 Clenched hands 
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 HP:0001263 Developmental retardation "A delay in the achievement of motor or mental milestones manifested prior to age 18 and generally associated with lifelong mental and/or physical impairments." [HPO:curators]
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 HP:0001274 Agenesis of corpus callosum "Absence of the corpus callosum as a result of the failure of the corpus callosum to develop, which can be the result of a failure in any one of the multiple steps of callosal development including cellular proliferation and migration, axonal growth or glial patterning at the midline." [HPO:curators]
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 HP:0001284 Areflexia 
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 HP:0001321 Cerebellar hypoplasia 
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 HP:0001339 Lissencephaly "A congenital absence of the convolutions of the cerebral cortex and a poorly formed sylvian fissure." [HPO:curators]
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 HP:0002804 Arthrogryposis multiplex congenita 
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 HP:0003577 Onset at birth 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction
 ENSG00000075213 Q14563 / SEMA3A / semaphorin 3A  / complex / reaction
 ENSG00000099250 NRP1 / O14786 / neuropilin 1  / complex / reaction
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / reaction / complex
 ENSG00000160789 LMNA / P02545 / lamin A/C  / reaction
 ENSG00000176749 CDK5R1 / Q15078 / cyclin dependent kinase 5 regulatory subunit 1  / reaction / complex
 ENSG00000158402 CDC25C / P30307 / cell division cycle 25C  / reaction
 ENSG00000167815 PRDX2 / P32119 / peroxiredoxin 2  / reaction
 ENSG00000177606 JUN / P05412 / Jun proto-oncogene, AP-1 transcription factor subunit  / reaction
 ENSG00000117450 PRDX1 / Q06830 / peroxiredoxin 1  / reaction
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000101224 CDC25B / P30305 / cell division cycle 25B  / reaction
 ENSG00000221866 PLXNA4 / Q9HCM2 / plexin A4  / complex / reaction
 ENSG00000167110 GOLGA2 / Q08379 / golgin A2  / reaction
 ENSG00000113368 LMNB1 / P20700 / lamin B1  / reaction
 ENSG00000164045 CDC25A / P30304 / cell division cycle 25A  / reaction
 ENSG00000130827 P51805 / PLXNA3 / plexin A3  / complex / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000134508 Q8TDN4 / CABLES1 / Cdk5 and Abl enzyme substrate 1  / reaction / complex
 ENSG00000076356 O75051 / PLXNA2 / plexin A2  / reaction / complex
 ENSG00000114554 PLXNA1 / Q9UIW2 / plexin A1  / reaction / complex
 ENSG00000118689 FOXO3 / O43524 / forkhead box O3  / reaction
 ENSG00000176697 BDNF / P23560 / brain derived neurotrophic factor  / reaction / complex






 

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