ENSMUSG00000004864


Mus musculus

Features
Gene ID: ENSMUSG00000004864
  
Biological name :Mapk13
  
Synonyms : Mapk13 / Mitogen-activated protein kinase 13 / Q9Z1B7
  
Possible biological names infered from orthology : O15264
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 28769307
Gene end: 28778698
  
Corresponding Affymetrix probe sets: 10443408 (MoGene1.0st)   1448871_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004986
Ensembl peptide - ENSMUSP00000115659
NCBI entrez gene - 26415     See in Manteia.
MGI - MGI:1346864
RefSeq - XM_017317479
RefSeq - NM_011950
RefSeq Peptide - NP_036080
swissprot - Q3UIB2
swissprot - Q9Z1B7
swissprot - D6RG58
Ensembl - ENSMUSG00000004864
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX324164.5ENSDARG00000110143Danio rerio
 MAPK13ENSGALG00000030966Gallus gallus
 MAPK13ENSG00000156711Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*ENSMUSG0000002261065
Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*ENSMUSG0000005343660
Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*ENSMUSG0000005313757
Mapk9 / Q9WTU6 / Mitogen-activated protein kinase 9 / P45984*ENSMUSG0000002036647
Mapk10 / mitogen-activated protein kinase 10 isoform 1x / P53779* / mitogen-activated protein kinase 10*ENSMUSG0000004670946
Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*ENSMUSG0000002193646


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008352  Mitogen-activated protein (MAP) kinase p38-like
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035556 intracellular signal transduction ISO
 biological_processGO:0051403 stress-activated MAPK cascade ISS
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0072709 cellular response to sorbitol IEA
 biological_processGO:0072740 cellular response to anisomycin IEA
 biological_processGO:1903936 cellular response to sodium arsenite IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
DSCAM interactions
VEGFA-VEGFR2 Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk12tm1Cnd/Mapk12tm1Cnd,Mapk13tm1Cnd/Mapk13tm1Cnd
Genetic Background: Not Specified

Allelic Composition: Mapk13tm1Cnd/Mapk13tm1Cnd
Genetic Background: Not Specified

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Becn1tm1Blev/Becn1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029167 O70343 / Ppargc1a / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha / Q9UBK2* / PPARG coactivator 1 alpha*  / reaction






 

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