ENSMUSG00000040093


Mus musculus

Features
Gene ID: ENSMUSG00000040093
  
Biological name :Bmf
  
Synonyms : Bmf / Mus musculus BCL2 modifying factor (Bmf), transcript variant 3, mRNA.
  
Possible biological names infered from orthology : Bcl2 modifying factor / Q96LC9
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 118528757
Gene end: 118549687
  
Corresponding Affymetrix probe sets: 10486112 (MoGene1.0st)   1422995_at (Mouse Genome 430 2.0 Array)   1454880_s_at (Mouse Genome 430 2.0 Array)   1458325_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106483
Ensembl peptide - ENSMUSP00000087686
NCBI entrez gene - 171543     See in Manteia.
MGI - MGI:2176433
RefSeq - XM_006498856
RefSeq - NM_001311140
RefSeq - NM_001331221
RefSeq - NM_138313
RefSeq - XM_006498855
RefSeq Peptide - NP_001298069
RefSeq Peptide - NP_001318150
RefSeq Peptide - NP_612186
swissprot - A2AV75
swissprot - A2AV74
Ensembl - ENSMUSG00000040093
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BMFENSGALG00000014537Gallus gallus
 BMFENSG00000104081Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR028192  Bcl-2-modifying factor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043276 anoikis IEA


Pathways (from Reactome)
Pathway description
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation of BMF and translocation to mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

Allelic Composition: Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S6-Bmftm1Rjd

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S6-Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S6-Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+,Bmftm1Rjd/Bmf+
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S6-Bmftm1Rjd

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0003537 hydrometrocolops "collection of fluid in the vagina; often due to a congenital obstruction" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S6-Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S6-Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd,Bmftm3.1Rjd/Bmftm3.1Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd Bmftm3.1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm2.1Rjd/Bmftm2.1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm2.1Rjd

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Jak1tm1Kuw/Jak1tm1Kuw,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

Allelic Composition: Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S6-Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd,Bmftm3.1Rjd/Bmftm3.1Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd Bmftm3.1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm2.1Rjd/Bmftm2.1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm2.1Rjd

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S6-Bmftm1Rjd

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S6-Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd,Bmftm3.1Rjd/Bmftm3.1Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd Bmftm3.1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm2.1Rjd/Bmftm2.1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm2.1Rjd

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Morq1AKR/J/Morq1AKR/J,Rs1tmgc1/Rs1tmgc1
Genetic Background: B6.Cg-Rs1tmgc1 Morq1AKR/J

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S6-Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd,Bmftm3.1Rjd/Bmftm3.1Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd Bmftm3.1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm2.1Rjd/Bmftm2.1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm2.1Rjd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / complex
 ENSMUSG00000057329 Bcl2 / P10417 / Apoptosis regulator Bcl-2 / P10415* / BCL2, apoptosis regulator*  / complex / reaction






 

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