ENSG00000104081


Homo sapiens

Features
Gene ID: ENSG00000104081
  
Biological name :BMF
  
Synonyms : Bcl2 modifying factor / BMF / Q96LC9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q15.1
Gene start: 40087890
Gene end: 40108892
  
Corresponding Affymetrix probe sets: 226530_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454142
Ensembl peptide - ENSP00000346697
Ensembl peptide - ENSP00000453913
Ensembl peptide - ENSP00000453919
Ensembl peptide - ENSP00000380703
Ensembl peptide - ENSP00000396511
Ensembl peptide - ENSP00000452660
Ensembl peptide - ENSP00000453522
Ensembl peptide - ENSP00000453892
NCBI entrez gene - 90427     See in Manteia.
OMIM - 606266
RefSeq - NM_001003942
RefSeq - NM_033503
RefSeq - NM_001003940
RefSeq - NM_001003943
RefSeq Peptide - NP_001003942
RefSeq Peptide - NP_277038
RefSeq Peptide - NP_001003940
RefSeq Peptide - NP_001003943
swissprot - Q96LC9
swissprot - H0YK50
swissprot - H0YNT3
Ensembl - ENSG00000104081
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BMFENSGALG00000014537Gallus gallus
 BmfENSMUSG00000040093Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR028192  Bcl-2-modifying factor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010507 negative regulation of autophagy IDA
 biological_processGO:0032464 positive regulation of protein homooligomerization ISS
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043276 anoikis IDA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria ISS
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016459 myosin complex ISS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation of BMF and translocation to mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000171791 BCL2 / P10415 / BCL2, apoptosis regulator  / complex / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex






 

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