Manteia - Molecule gene

ENSMUSG00000050272

Mus musculus

Features

Gene ID:	ENSMUSG00000050272

Biological name :	Dscam

Synonyms :	Down syndrome cell adhesion molecule homolog / Dscam / Q9ERC8

Possible biological names infered from orthology :	DS cell adhesion molecule / O60469

Species:	Mus musculus

Chr. number:	16
Strand:	-1
Band:	C4
Gene start:	96592079
Gene end:	97170752

Corresponding Affymetrix probe sets:	10441195 (MoGene1.0st) 1419293_at (Mouse Genome 430 2.0 Array) 1431801_at (Mouse Genome 430 2.0 Array) 1441082_at (Mouse Genome 430 2.0 Array) 1449411_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000056040 NCBI entrez gene - 13508 See in Manteia. MGI - MGI:1196281 RefSeq - XM_011246093 RefSeq - NM_031174 RefSeq - XM_006522886 RefSeq Peptide - NP_112451 swissprot - Q9ERC8 Ensembl - ENSMUSG00000050272

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
dscama	ENSDARG00000024865	Danio rerio
dscamb	ENSDARG00000028118	Danio rerio
DSCAM	ENSGALG00000016138	Gallus gallus
DSCAM	ENSG00000171587	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Dscaml1 / DS cell adhesion molecule like 1 / Q8TD84*	ENSMUSG00000032087	61
Sdk2 / Q6V4S5 / Protein sidekick-2 / Q58EX2* / sidekick cell adhesion molecule 2*	ENSMUSG00000041592	18
Sdk1 / Q3UH53 / Protein sidekick-1 / Q7Z5N4* / sidekick cell adhesion molecule 1*	ENSMUSG00000039683	17
Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*	ENSMUSG00000060534	16
Neo1 / neogenin / Q92859* / neogenin 1*	ENSMUSG00000032340	15
Igdcc4 / Q9EQS9 / Immunoglobulin superfamily DCC subclass member 4 / Q8TDY8*	ENSMUSG00000032816	12
Prtg / Q2EY15 / Protogenin / Q2VWP7*	ENSMUSG00000036030	12
Igdcc3 / Q8BQC3 / Immunoglobulin superfamily DCC subclass member 3 / Q8IVU1*	ENSMUSG00000032394	9

Protein motifs (from Interpro)

Interpro ID	Name
IPR003598	Immunoglobulin subtype 2
IPR003599	Immunoglobulin subtype
IPR003961	Fibronectin type III
IPR007110	Immunoglobulin-like domain
IPR013098	Immunoglobulin I-set
IPR013106	Immunoglobulin V-set domain
IPR013783	Immunoglobulin-like fold
IPR033027	Down syndrome cell adhesion molecule, chordates
IPR036116	Fibronectin type III superfamily
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	ISS
biological_process	GO:0007162	negative regulation of cell adhesion	IMP
biological_process	GO:0007399	nervous system development	IEA
biological_process	GO:0007416	synapse assembly	ISS
biological_process	GO:0007626	locomotory behavior	IMP
biological_process	GO:0010842	retina layer formation	ISS
biological_process	GO:0042327	positive regulation of phosphorylation	IEA
biological_process	GO:0048813	dendrite morphogenesis	IMP
biological_process	GO:0048842	positive regulation of axon extension involved in axon guidance	IEA
biological_process	GO:0060060	post-embryonic retina morphogenesis in camera-type eye	IMP
biological_process	GO:0060219	camera-type eye photoreceptor cell differentiation	ISS
biological_process	GO:0070593	dendrite self-avoidance	IMP
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005887	integral component of plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0030424	axon	IEA
cellular_component	GO:0030426	growth cone	IDA
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0045202	synapse	ISS
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

DSCAM interactions

VEGFA-VEGFR2 Pathway

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000018	small ears	"outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: C3H/HeDiSn-Dscam^2J/GrsrJ Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0000440	domed skull		Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: C3H/HeDiSn-Dscam^2J/GrsrJ Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0000822	abnormal brain ventricle morphology	"malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0000823	abnormal lateral ventricle morphology	"malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0000827	dilated third ventricle	"enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0000857	abnormal cerebellar foliation	"malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0001290	delayed eyelid opening	"late average time for the first postnatal eye opening" [J:17792]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gata1^tm2Sho/Y Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 Allelic Composition: Dscam^del17/Dscam^del17 Genetic Background: B6.CBy-Dscam^del17/RwbJ Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: C3H/HeDiSn-Dscam^2J/GrsrJ Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: involves: C3H/HeDiSnJ
MP:0001329	retina hyperplasia	"greater than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0001504	abnormal posture	"atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]	Show Allelic Composition: Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd
MP:0001512	trunk curl	"posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd
MP:0001522	impaired swimming	"reduced ability or inability to swim" [J:45446, J:39081]	Show Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: C3H/HeDiSn-Dscam^2J/GrsrJ
MP:0001525	impaired balance	"reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]	Show Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: C3H/HeDiSn-Dscam^2J/GrsrJ
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0001943	abnormal respiration	"anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Oprm1^tm1Yxp/Oprm1^tm1Yxp Genetic Background: involves: 129/Sv * C57BL/6
MP:0001951	abnormal breathing	"irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Dscam^tm1.1Kzy/Dscam⁺ Genetic Background: B6.129P2-Dscam^tm1.1Kzy Allelic Composition: Dscam^tm1.1Kzy/Dscam⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Oprm1^tm1Yxp/Oprm1^tm1Yxp Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dscam^tm1.1Kzy/Dscam⁺ Genetic Background: B6.129P2-Dscam^tm1.1Kzy
MP:0001957	apnea	"absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]	Show Allelic Composition: Oprm1^tm1Yxp/Oprm1^tm1Yxp Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dscam^tm1.1Kzy/Dscam^tm1.1Kzy Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0002199	abnormal brain commissure morphology	"absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0002741	small olfactory bulb	"reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0002804	abnormal motor learning	"defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0002983	increased retinal ganglion cell number	"greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Dscam^del17/Dscam^del17 Genetic Background: B6.CBy-Dscam^del17/RwbJ
MP:0003243	abnormal dopaminergic neuron morphology	"malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0003733	abnormal inner nuclear layer morphology	"malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Dscam^del17/Dscam^del17,Dscaml1^{Gt(CC0772)Wtsi}/Dscaml1^{Gt(CC0772)Wtsi} Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: involves: C3H/HeDiSnJ
MP:0003734	abnormal inner plexiform layer morphology	"malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0003880	abnormal central pattern generator function	"anomalous function of the neural networks that produce rhythmic patterned output without sensory input and underlie rhythmic motor patterns" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:101019]	Show Allelic Composition: Oprm1^tm1Yxp/Oprm1^tm1Yxp Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dscam^tm1.1Kzy/Dscam⁺ Genetic Background: B6.129P2-Dscam^tm1.1Kzy
MP:0004143	hypertonia	"increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0005240	abnormal amacrine cell morphology	"anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: C3H/HeDiSn-Dscam^2J/GrsrJ Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: C3Sn.Cg-Pde6b⁺ Dscam^2J/Rwb Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Tg(Pax6-cre,GFP)2Pgr/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Dscam^tm1.1Pfu/Dscam^tm1.1Pfu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Gt(ROSA)26Sor^{tm3(CAG-EGFP/Dsred2)Luo}/?,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0005241	abnormal retinal ganglion layer morphology	"anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dscam^del17/Dscam^del17,Dscaml1^{Gt(CC0772)Wtsi}/Dscaml1^{Gt(CC0772)Wtsi} Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J Allelic Composition: Dscam^del17/Dscam^del17 Genetic Background: B6.CBy-Dscam^del17/RwbJ Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: involves: C3H/HeDiSnJ
MP:0005423	abnormal somatic nervous system physiology	"anomalous function of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Oprm1^tm1Yxp/Oprm1^tm1Yxp Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dscam^tm1.1Kzy/Dscam⁺ Genetic Background: B6.129P2-Dscam^tm1.1Kzy Allelic Composition: Dscam^tm1.1Kzy/Dscam^tm1.1Kzy Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0005537	abnormal cerebral aqueduct	"anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0005551	abnormal eye electrophysiology	"abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]	Show Allelic Composition: Dscam^del17/Dscam^del17 Genetic Background: B6.CBy-Dscam^del17/RwbJ
MP:0005574	decreased breathing frequency	"fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]	Show Allelic Composition: Oprm1^tm1Yxp/Oprm1^tm1Yxp Genetic Background: involves: 129/Sv * C57BL/6
MP:0006069	abnormal retinal neuronal layer morphology	"malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]	Show Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: involves: C3H/HeDiSnJ
MP:0006073	abnormal retinal bipolar cell morphology	"anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]	Show Allelic Composition: Dscam^del17/Dscam^del17,Dscaml1^{Gt(CC0772)Wtsi}/Dscaml1^{Gt(CC0772)Wtsi} Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J Allelic Composition: Dscam^del17/Dscam^del17 Genetic Background: B6.CBy-Dscam^del17/RwbJ
MP:0006075	abnormal retinal cone bipolar cell morphology	"anomalous structure of the retinal bipolar cells that connect to both ganglion and amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]	Show Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: involves: C3H/HeDiSnJ
MP:0006254	thin cerebral cortex	"decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0008056	abnormal retinal ganglion cell morphology	"any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Tg(Pax6-cre,GFP)2Pgr/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Tg(Thy1-cre)1Vln/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Opn4^tm1(cre)Sapa/Opn4⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0008105	increased amacrine cell number	"increase in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0008128	abnormal brain internal capsule morphology	"any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0008415	abnormal neurite morphology	"any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]	Show Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0008508	thick retinal ganglion layer	"increased thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0008509	disorganized retinal ganglion layer	"derangement of the pattern of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: C3H/HeDiSn-Dscam^2J/GrsrJ
MP:0008512	disorganized retinal inner nuclear layer	"derangement of the normal pattern of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: C3H/HeDiSn-Dscam^2J/GrsrJ
MP:0008535	enlarged lateral ventricles	"increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0008779	abnormal maternal behavior	"any response from the mother inconsistent with ability of young to thrive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1a^tg-rol/Cacna1a⁺ Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII
MP:0008947	increased neuron number	"greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]	Show Allelic Composition: Oprm1^tm1Yxp/Oprm1^tm1Yxp Genetic Background: involves: 129/Sv * C57BL/6
MP:0009393	abnormal resting posture	"atypical position of the limbs compared to normal carriage when the body is inactive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: C3H/HeDiSn-Dscam^2J/GrsrJ
MP:0009450	abnormal axon fasiculation	"anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dscam^2J/Dscam^2J Genetic Background: C3H/HeDiSn-Dscam^2J/GrsrJ Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Tg(Pax6-cre,GFP)2Pgr/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Dscam^tm1.1Pfu/Dscam^tm1.1Pfu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Gt(ROSA)26Sor^{tm3(CAG-EGFP/Dsred2)Luo}/?,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu,Opn4^tm1(cre)Sapa/Opn4⁺ Genetic Background: involves: 129 * C57BL/6
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Oprm1^tm1Yxp/Oprm1^tm1Yxp Genetic Background: involves: 129/Sv * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Cacna1a^tg-rol/Cacna1a⁺ Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Dscam^del17/Dscam^del17 Genetic Background: B6.CBy-Dscam^del17/RwbJ
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Oprm1^tm1Yxp/Oprm1^tm1Yxp Genetic Background: involves: 129/Sv * C57BL/6
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Cacna1a^tg-rol/Cacna1a⁺ Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII
MP:0011380	enlarged brain ventricle	"increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]	Show Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0011996	abnormal retinal inner nuclear layer thickness	"anomaly in the thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:csmith]	Show Allelic Composition: Dscam^3J/Dscam^3J Genetic Background: involves: C3H/HeSnSmn * CB17
MP:0012008	delayed parturition	"the process of labor and delivery in female animals occurs later in gestation than expected or lack of progress in a labor already initiated" [MGI:csmith]	Show Allelic Composition: Dscam^tm1.1Kzy/Dscam⁺ Genetic Background: B6.129P2-Dscam^tm1.1Kzy
MP:0012468	decreased striatum area	"reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0012676	dilated brain ventricles	"the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0030076	abnormal cranial cavity morphology	"any anomaly of the space formed within the skull and occupied by the brain, pineal and hypophysis cerebri, parts of the cranial and spinal nerves, blood vessels, meninges and cerebrospinal fluid" [http://welovelmc.com/uncategorised/cranialcavity.htm, https://en.wikipedia.org/wiki/Cranial_cavity]	Show Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu,Tcf3^tm4Zhu/Tcf3^tm4Zhu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020902	Ntn1 / O09118 / Netrin-1 / O95631*	/ complex / reaction
ENSMUSG00000030774	Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*	/ complex / reaction
ENSMUSG00000021936	Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*	/ reaction
ENSMUSG00000050272	Dscam / Q9ERC8 / Down syndrome cell adhesion molecule homolog / O60469* / DS cell adhesion molecule*	/ complex / reaction
ENSMUSG00000001847	Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*	/ complex / reaction
ENSMUSG00000060534	Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*	/ reaction / complex

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