ENSG00000171587


Homo sapiens

Features
Gene ID: ENSG00000171587
  
Biological name :DSCAM
  
Synonyms : DSCAM / DS cell adhesion molecule / O60469
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.2
Gene start: 40010999
Gene end: 40847139
  
Corresponding Affymetrix probe sets: 211484_s_at (Human Genome U133 Plus 2.0 Array)   237268_at (Human Genome U133 Plus 2.0 Array)   240218_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478698
Ensembl peptide - ENSP00000383303
Ensembl peptide - ENSP00000385342
NCBI entrez gene - 1826     See in Manteia.
OMIM - 602523
RefSeq - XM_017028281
RefSeq - NM_001271534
RefSeq - NM_001389
RefSeq Peptide - NP_001258463
RefSeq Peptide - NP_001380
swissprot - O60469
swissprot - Q8WY19
swissprot - A0A087WUI7
Ensembl - ENSG00000171587
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dscamaENSDARG00000024865Danio rerio
 dscambENSDARG00000028118Danio rerio
 DSCAMENSGALG00000016138Gallus gallus
 DscamENSMUSG00000050272Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TD84 / DSCAML1 / DS cell adhesion molecule like 1ENSG0000017710361
SDK2 / Q58EX2 / sidekick cell adhesion molecule 2ENSG0000006918818
SDK1 / Q7Z5N4 / sidekick cell adhesion molecule 1ENSG0000014655517
NEO1 / Q92859 / neogenin 1ENSG0000006714115
DCC / P43146 / DCC netrin 1 receptorENSG0000018732315
IGDCC4 / Q8TDY8 / immunoglobulin superfamily DCC subclass member 4ENSG0000010374212
PRTG / Q2VWP7 / protogeninENSG0000016645012
IGDCC3 / Q8IVU1 / immunoglobulin superfamily DCC subclass member 3ENSG000001744989


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR033027  Down syndrome cell adhesion molecule, chordates
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007416 synapse assembly ISS
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0010842 retina layer formation ISS
 biological_processGO:0042327 positive regulation of phosphorylation IDA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:0048842 positive regulation of axon extension involved in axon guidance IDA
 biological_processGO:0060060 post-embryonic retina morphogenesis in camera-type eye IEA
 biological_processGO:0060219 camera-type eye photoreceptor cell differentiation ISS
 biological_processGO:0070593 dendrite self-avoidance IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse ISS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
DSCAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065320 NTN1 / O95631 / netrin 1  / complex / reaction
 ENSG00000177103 Q8TD84 / DSCAML1 / DS cell adhesion molecule like 1  / complex / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000171587 DSCAM / O60469 / DS cell adhesion molecule  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction / complex






 

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