ENSMUSG00000032087


Mus musculus

Features
Gene ID: ENSMUSG00000032087
  
Biological name :Dscaml1
  
Synonyms : Dscaml1 / DS cell adhesion molecule like 1
  
Possible biological names infered from orthology : Q8TD84
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.2
Gene start: 45426628
Gene end: 45753712
  
Corresponding Affymetrix probe sets: 10584901 (MoGene1.0st)   1427392_at (Mouse Genome 430 2.0 Array)   1427734_a_at (Mouse Genome 430 2.0 Array)   1432196_a_at (Mouse Genome 430 2.0 Array)   1441706_at (Mouse Genome 430 2.0 Array)   1457463_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034592
Ensembl peptide - ENSMUSP00000150245
Ensembl peptide - ENSMUSP00000149771
Ensembl peptide - ENSMUSP00000149247
Ensembl peptide - ENSMUSP00000148905
NCBI entrez gene - 114873     See in Manteia.
MGI - MGI:2150309
RefSeq - XM_017313109
RefSeq - NM_001081270
RefSeq - XM_006509947
RefSeq - XM_006509948
RefSeq Peptide - NP_001074739
swissprot - E9QPR7
swissprot - Q8CET1
swissprot - A0A1L1SQZ7
swissprot - A0A1L1SQ53
swissprot - A0A1L1ST95
Ensembl - ENSMUSG00000032087
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dscaml1ENSDARG00000098057Danio rerio
 DSCAML1ENSGALG00000007314Gallus gallus
 Q8TD84ENSG00000177103Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dscam / Q9ERC8 / Down syndrome cell adhesion molecule homolog / O60469* / DS cell adhesion molecule*ENSMUSG0000005027258
Sdk2 / Q6V4S5 / Protein sidekick-2 / Q58EX2* / sidekick cell adhesion molecule 2*ENSMUSG0000004159217
Sdk1 / Q3UH53 / Protein sidekick-1 / Q7Z5N4* / sidekick cell adhesion molecule 1*ENSMUSG0000003968317
Neo1 / neogenin / Q92859* / neogenin 1*ENSMUSG0000003234015
Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*ENSMUSG0000006053414
Igdcc4 / Q9EQS9 / Immunoglobulin superfamily DCC subclass member 4 / Q8TDY8*ENSMUSG0000003281612
Prtg / Q2EY15 / Protogenin / Q2VWP7*ENSMUSG0000003603011
Igdcc3 / Q8BQC3 / Immunoglobulin superfamily DCC subclass member 3 / Q8IVU1*ENSMUSG000000323948


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR033029  Down syndrome cell adhesion molecule-like protein 1
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
DSCAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Dscamdel17/Dscamdel17,Dscaml1Gt(CC0772)Wtsi/Dscaml1Gt(CC0772)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Dscamdel17/Dscamdel17,Dscaml1Gt(CC0772)Wtsi/Dscaml1Gt(CC0772)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Dscamdel17/Dscamdel17,Dscaml1Gt(CC0772)Wtsi/Dscaml1Gt(CC0772)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
Show

Allelic Composition: Dscamdel17/Dscamdel17,Dscaml1Gt(CC0772)Wtsi/Dscaml1Gt(CC0772)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0008105 increased amacrine cell number "increase in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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