ENSG00000166313


Homo sapiens

Features
Gene ID: ENSG00000166313
  
Biological name :APBB1
  
Synonyms : amyloid beta precursor protein binding family B member 1 / APBB1 / O00213
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.4
Gene start: 6395124
Gene end: 6419414
  
Corresponding Affymetrix probe sets: 202652_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477213
Ensembl peptide - ENSP00000477069
Ensembl peptide - ENSP00000481817
Ensembl peptide - ENSP00000484493
Ensembl peptide - ENSP00000483682
Ensembl peptide - ENSP00000299402
Ensembl peptide - ENSP00000311912
Ensembl peptide - ENSP00000374556
Ensembl peptide - ENSP00000433338
Ensembl peptide - ENSP00000476442
Ensembl peptide - ENSP00000476536
Ensembl peptide - ENSP00000476646
Ensembl peptide - ENSP00000476647
Ensembl peptide - ENSP00000476776
Ensembl peptide - ENSP00000476846
Ensembl peptide - ENSP00000476871
Ensembl peptide - ENSP00000477022
NCBI entrez gene - 322     See in Manteia.
OMIM - 602709
RefSeq - XM_017017642
RefSeq - NM_001257326
RefSeq - NM_145689
RefSeq - XM_006718209
RefSeq - XM_006718210
RefSeq - XM_006718211
RefSeq - XM_006718212
RefSeq - XM_006718213
RefSeq - XM_006718214
RefSeq - XM_006718215
RefSeq - XM_011520037
RefSeq - XM_011520038
RefSeq - XM_011520040
RefSeq - XM_011520042
RefSeq - XM_017017639
RefSeq - XM_017017640
RefSeq - XM_017017641
RefSeq - NM_001164
RefSeq - NM_001257319
RefSeq - NM_001257320
RefSeq - NM_001257321
RefSeq - NM_001257323
RefSeq - NM_001257325
RefSeq Peptide - NP_663722
RefSeq Peptide - NP_001244254
RefSeq Peptide - NP_001244255
RefSeq Peptide - NP_001155
RefSeq Peptide - NP_001244248
RefSeq Peptide - NP_001244249
RefSeq Peptide - NP_001244250
RefSeq Peptide - NP_001244252
swissprot - V9GYD5
swissprot - A0A087WYH9
swissprot - J3KPL8
swissprot - O00213
swissprot - V9GY97
swissprot - A0A087X0V7
swissprot - V9GYR7
swissprot - A0A075B7G8
Ensembl - ENSG00000166313
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apbb1ENSDARG00000076560Danio rerio
 APBB1ENSGALG00000046164Gallus gallus
 Apbb1ENSMUSG00000037032Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
APBB2 / Q92870 / amyloid beta precursor protein binding family B member 2ENSG0000016369742
APBB3 / O95704 / amyloid beta precursor protein binding family B member 3ENSG0000011310821


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007050 cell cycle arrest ISS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007409 axonogenesis NAS
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0030308 negative regulation of cell growth ISS
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043967 histone H4 acetylation ISS
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050760 negative regulation of thymidylate synthase biosynthetic process ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044304 main axon IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:1990761 growth cone lamellipodium IEA
 cellular_componentGO:1990812 growth cone filopodium IEA
 molecular_functionGO:0001540 amyloid-beta binding NAS
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding ISS
 molecular_functionGO:0042393 histone binding IPI
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0070064 proline-rich region binding IPI


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction / complex
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000104320 NBN / nibrin / O60934  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction / complex
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / complex / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction / complex






 

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