ENSMUSG00000025218


Mus musculus

Features
Gene ID: ENSMUSG00000025218
  
Biological name :Poll
  
Synonyms : Poll / polymerase (DNA directed), lambda / Q9QXE2
  
Possible biological names infered from orthology : DNA polymerase lambda / Q9UGP5
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 45552275
Gene end: 45560531
  
Corresponding Affymetrix probe sets: 10468049 (MoGene1.0st)   1449352_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026239
NCBI entrez gene - 56626     See in Manteia.
MGI - MGI:1889000
RefSeq - XM_011247301
RefSeq - NM_020032
RefSeq - XM_006527232
RefSeq Peptide - NP_001317435
RefSeq Peptide - NP_064416
swissprot - Q9QXE2
Ensembl - ENSMUSG00000025218
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pollENSDARG00000039613Danio rerio
 POLLENSGALG00000007753Gallus gallus
 POLLENSG00000166169Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Polm / Q9JIW4 / polymerase (DNA directed), mu / Q9NP87* / DNA polymerase mu*ENSMUSG0000002047423
Dntt / P09838 / DNA nucleotidylexotransferase / P04053*ENSMUSG0000002501422
Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*ENSMUSG0000003153620


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR002008  DNA polymerase family X, beta-like
 IPR002054  DNA-directed DNA polymerase X
 IPR010996  DNA polymerase beta-like, N-terminal domain
 IPR018944  DNA polymerase lambda, fingers domain
 IPR019843  DNA polymerase family X, binding site
 IPR022312  DNA polymerase family X
 IPR027421  DNA polymerase lambda lyase domain superfamily
 IPR028207  DNA polymerase beta, palm domain
 IPR029398  DNA polymerase beta, thumb domain
 IPR036420  BRCT domain superfamily
 IPR037160  DNA polymerase, thumb domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006287 base-excision repair, gap-filling IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0034061 DNA polymerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051575 5"-deoxyribose-5-phosphate lyase activity IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hspa1btm1Clib/Hspa1btm1Clib
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Polltm1Crey/Polltm1Crey,Polmtm1Crey/Polmtm1Crey
Genetic Background: involves: 129P2/OlaHsd

 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hspa1btm1Clib/Hspa1btm1Clib
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Polltm1Crey/Polltm1Crey,Polmtm1Crey/Polmtm1Crey
Genetic Background: involves: 129P2/OlaHsd

 MP:0008761 abnormal immunoglobulin light chain V-J recombination "any anomaly in the process by which V and J gene segments of the immunoglobulin light chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Polltm1Crey/Polltm1Crey,Polmtm1Crey/Polmtm1Crey
Genetic Background: involves: 129P2/OlaHsd

 MP:0009796 abnormal base-excision repair "any anomaly in the process whereby an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate; the small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase" [GO:0006284]
Show

Allelic Composition: Hspa1btm1Clib/Hspa1btm1Clib
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021615 Xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / reaction
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / reaction
 ENSMUSG00000026187 Xrcc5 / P27641 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / reaction
 ENSMUSG00000022471 Xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / reaction
 ENSMUSG00000022672 Prkdc / P97313 / DNA-dependent protein kinase catalytic subunit / P78527* / protein kinase, DNA-activated, catalytic polypeptide*  / reaction
 ENSMUSG00000049717 Lig4 / Q8BTF7 / ligase IV, DNA, ATP-dependent / P49917* / DNA ligase 4*  / reaction






 

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