ENSG00000166169


Homo sapiens

Features
Gene ID: ENSG00000166169
  
Biological name :POLL
  
Synonyms : DNA polymerase lambda / POLL / Q9UGP5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.32
Gene start: 101578882
Gene end: 101588270
  
Corresponding Affymetrix probe sets: 221049_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000485885
Ensembl peptide - ENSP00000299206
Ensembl peptide - ENSP00000343102
Ensembl peptide - ENSP00000359181
Ensembl peptide - ENSP00000411678
Ensembl peptide - ENSP00000414293
Ensembl peptide - ENSP00000359187
Ensembl peptide - ENSP00000359188
Ensembl peptide - ENSP00000359191
Ensembl peptide - ENSP00000390093
Ensembl peptide - ENSP00000400517
Ensembl peptide - ENSP00000400676
Ensembl peptide - ENSP00000406791
NCBI entrez gene - 27343     See in Manteia.
OMIM - 606343
RefSeq - XM_017016093
RefSeq - NM_001174084
RefSeq - NM_001174085
RefSeq - NM_001308382
RefSeq - NM_013274
RefSeq - XM_011539663
RefSeq - XM_011539664
RefSeq - XM_011539665
RefSeq - XM_011539666
RefSeq - XM_011539667
RefSeq - XM_017016084
RefSeq - XM_017016085
RefSeq - XM_017016086
RefSeq - XM_017016087
RefSeq - XM_017016088
RefSeq - XM_017016089
RefSeq - XM_017016090
RefSeq - XM_017016091
RefSeq - XM_017016092
RefSeq - XM_006717775
RefSeq - XM_006717776
RefSeq - XM_006717777
RefSeq - XM_011539650
RefSeq - XM_011539651
RefSeq - XM_011539652
RefSeq - XM_011539653
RefSeq - XM_011539654
RefSeq - XM_011539655
RefSeq - XM_011539656
RefSeq - XM_011539657
RefSeq - XM_011539659
RefSeq - XM_011539660
RefSeq - XM_011539662
RefSeq Peptide - NP_001167556
RefSeq Peptide - NP_001295311
RefSeq Peptide - NP_037406
RefSeq Peptide - NP_001167555
swissprot - Q5JQP0
swissprot - Q5JQP1
swissprot - Q5JQP2
swissprot - Q5JQP3
swissprot - Q5JQP4
swissprot - Q5JQP7
swissprot - Q5JQP8
swissprot - Q9HBN3
swissprot - Q9UGP5
swissprot - Q5JQN9
Ensembl - ENSG00000166169
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pollENSDARG00000039613Danio rerio
 POLLENSGALG00000007753Gallus gallus
 PollENSMUSG00000025218Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DNTT / P04053 / DNA nucleotidylexotransferaseENSG0000010744720
POLB / P06746 / DNA polymerase betaENSG0000007050120
POLM / Q9NP87 / DNA polymerase muENSG0000012267816


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR002008  DNA polymerase family X, beta-like
 IPR002054  DNA-directed DNA polymerase X
 IPR010996  DNA polymerase beta-like, N-terminal domain
 IPR018944  DNA polymerase lambda, fingers domain
 IPR019843  DNA polymerase family X, binding site
 IPR022312  DNA polymerase family X
 IPR027421  DNA polymerase lambda lyase domain superfamily
 IPR028207  DNA polymerase beta, palm domain
 IPR029398  DNA polymerase beta, thumb domain
 IPR036420  BRCT domain superfamily
 IPR037160  DNA polymerase, thumb domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0006260 DNA replication NAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006287 base-excision repair, gap-filling IDA
 biological_processGO:0006289 nucleotide-excision repair IDA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes NAS
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0034061 DNA polymerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051575 5"-deoxyribose-5-phosphate lyase activity IDA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000152422 XRCC4 / Q13426 / X-ray repair cross complementing 4  / reaction
 ENSG00000253729 PRKDC / P78527 / protein kinase, DNA-activated, catalytic polypeptide  / reaction
 ENSG00000196419 XRCC6 / P12956 / X-ray repair cross complementing 6  / reaction
 ENSG00000174405 LIG4 / P49917 / DNA ligase 4  / reaction
 ENSG00000152457 Q96SD1 / DCLRE1C / DNA cross-link repair 1C  / reaction
 ENSG00000187736 NHEJ1 / Q9H9Q4 / non-homologous end joining factor 1  / reaction
 ENSG00000079246 XRCC5 / P13010 / X-ray repair cross complementing 5  / reaction






 

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