ENSMUSG00000021615


Mus musculus

Features
Gene ID: ENSMUSG00000021615
  
Biological name :Xrcc4
  
Synonyms : X-ray repair complementing defective repair in Chinese hamster cells 4 / Xrcc4
  
Possible biological names infered from orthology : Q13426 / X-ray repair cross complementing 4
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C3
Gene start: 89774027
Gene end: 90089608
  
Corresponding Affymetrix probe sets: 10410947 (MoGene1.0st)   1424601_at (Mouse Genome 430 2.0 Array)   1424602_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022115
Ensembl peptide - ENSMUSP00000125486
Ensembl peptide - ENSMUSP00000124573
Ensembl peptide - ENSMUSP00000123934
NCBI entrez gene - 108138     See in Manteia.
MGI - MGI:1333799
RefSeq - XM_006517043
RefSeq - NM_028012
RefSeq - XM_006517041
RefSeq - XM_006517042
RefSeq Peptide - NP_082288
swissprot - E0CZC8
swissprot - A0A0R4J1Y0
swissprot - A0A0R4J024
swissprot - E0CY05
Ensembl - ENSMUSG00000021615
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xrcc4ENSDARG00000010732Danio rerio
 XRCC4ENSGALG00000015620Gallus gallus
 XRCC4ENSG00000152422Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009089  XRCC4, N-terminal domain superfamily
 IPR010585  DNA repair protein XRCC4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair IEA
 biological_processGO:0051351 positive regulation of ligase activity IEA
 biological_processGO:0071285 cellular response to lithium ion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex IEA
 cellular_componentGO:0032807 DNA ligase IV complex IEA
 cellular_componentGO:0070419 nonhomologous end joining complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
Show

Allelic Composition: Trp53tm2Xu/Trp53tm2Xu,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000439 enlarged skull 
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc4tm2.1Fwa/Xrcc4tm2Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc4tm2.1Fwa/Xrcc4tm2Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc4tm2.1Fwa/Xrcc4tm2Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Trp53tm2Xu/Trp53tm2Xu,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Trp53tm1Xu/Trp53tm1Xu,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc4tm2.1Fwa/Xrcc4tm2Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Trp53tm2Xu/Trp53tm2Xu,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tg(Cr2-cre)3Cgn/?,Xrcc4tm1Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Tg(Cr2-cre)3Cgn/?,Xrcc4tm1Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Rag2tm1Cgn/Rag2tm1Cgn,Tg(Cr2-cre)3Cgn/?,Xrcc4tm1Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Trp53tm1Tyj/Trp53tm1Tyj,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Tg(Cr2-cre)3Cgn/0,Xrcc4tm2Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Trp53tm1Tyj/Trp53tm1Tyj,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Tg(Cr2-cre)3Cgn/0,Xrcc4tm2Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Cr2-cre)3Cgn/?,Xrcc4tm1Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Rag2tm1Cgn/Rag2tm1Cgn,Tg(Cr2-cre)3Cgn/?,Xrcc4tm1Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Trp53tm1Tyj/Trp53tm1Tyj,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Tg(Cr2-cre)3Cgn/0,Xrcc4tm2Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc4tm2.1Fwa/Xrcc4tm2Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl
Genetic Background: Not Specified

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022471 Xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / reaction
 ENSMUSG00000025218 Poll / Q9QXE2 / polymerase (DNA directed), lambda / Q9UGP5* / DNA polymerase lambda*  / reaction
 ENSMUSG00000026187 Xrcc5 / P27641 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / reaction
 ENSMUSG00000020474 Polm / Q9JIW4 / polymerase (DNA directed), mu / Q9NP87* / DNA polymerase mu*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / reaction
 ENSMUSG00000049717 Lig4 / Q8BTF7 / ligase IV, DNA, ATP-dependent / P49917* / DNA ligase 4*  / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000022672 Prkdc / P97313 / DNA-dependent protein kinase catalytic subunit / P78527* / protein kinase, DNA-activated, catalytic polypeptide*  / reaction
 ENSMUSG00000021615 Xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / complex






 

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