ENSMUSG00000020474


Mus musculus

Features
Gene ID: ENSMUSG00000020474
  
Biological name :Polm
  
Synonyms : Polm / polymerase (DNA directed), mu / Q9JIW4
  
Possible biological names infered from orthology : DNA polymerase mu / Q9NP87
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 5827860
Gene end: 5838016
  
Corresponding Affymetrix probe sets: 10384020 (MoGene1.0st)   1417249_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020767
Ensembl peptide - ENSMUSP00000105463
NCBI entrez gene - 54125     See in Manteia.
MGI - MGI:1860191
RefSeq - XM_006514758
RefSeq - NM_017401
RefSeq Peptide - NP_059097
swissprot - Q5NCI3
swissprot - Q9JIW4
Ensembl - ENSMUSG00000020474
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polmENSDARG00000103470Danio rerio
 POLMENSG00000122678Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dntt / P09838 / DNA nucleotidylexotransferase / P04053*ENSMUSG0000002501443
Poll / Q9QXE2 / polymerase (DNA directed), lambda / Q9UGP5* / DNA polymerase lambda*ENSMUSG0000002521826
Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*ENSMUSG0000003153617


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR001726  DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu
 IPR002054  DNA-directed DNA polymerase X
 IPR010996  DNA polymerase beta-like, N-terminal domain
 IPR018944  DNA polymerase lambda, fingers domain
 IPR019843  DNA polymerase family X, binding site
 IPR022312  DNA polymerase family X
 IPR027249  DNA-directed DNA/RNA polymerase mu
 IPR027421  DNA polymerase lambda lyase domain superfamily
 IPR028207  DNA polymerase beta, palm domain
 IPR029398  DNA polymerase beta, thumb domain
 IPR036420  BRCT domain superfamily
 IPR037160  DNA polymerase, thumb domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IMP
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0034061 DNA polymerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hspa1btm1Clib/Hspa1btm1Clib
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002223 lymphoid hypoplasia "decreased cell number in lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcl1tm1Wabo/Cxcl1tm1Wabo,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Polltm1Crey/Polltm1Crey,Polmtm1Crey/Polmtm1Crey
Genetic Background: involves: 129P2/OlaHsd

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Polltm1Crey/Polltm1Crey,Polmtm1Crey/Polmtm1Crey
Genetic Background: involves: 129P2/OlaHsd

 MP:0008761 abnormal immunoglobulin light chain V-J recombination "any anomaly in the process by which V and J gene segments of the immunoglobulin light chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Polltm1Crey/Polltm1Crey,Polmtm1Crey/Polmtm1Crey
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dntttm1Gfn/Dntttm1Gfn,Polmtm1Crey/Polmtm1Crey
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Polmtm1Crey/Polmtm1Crey
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / reaction
 ENSMUSG00000026187 Xrcc5 / P27641 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / reaction
 ENSMUSG00000022672 Prkdc / P97313 / DNA-dependent protein kinase catalytic subunit / P78527* / protein kinase, DNA-activated, catalytic polypeptide*  / reaction
 ENSMUSG00000022471 Xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / reaction
 ENSMUSG00000021615 Xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / reaction
 ENSMUSG00000049717 Lig4 / Q8BTF7 / ligase IV, DNA, ATP-dependent / P49917* / DNA ligase 4*  / reaction






 

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