ENSMUSG00000025014


Mus musculus

Features
Gene ID: ENSMUSG00000025014
  
Biological name :Dntt
  
Synonyms : DNA nucleotidylexotransferase / Dntt / P09838
  
Possible biological names infered from orthology : P04053
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 41029275
Gene end: 41059523
  
Corresponding Affymetrix probe sets: 10463123 (MoGene1.0st)   1420166_at (Mouse Genome 430 2.0 Array)   1449757_x_at (Mouse Genome 430 2.0 Array)   1450545_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062078
Ensembl peptide - ENSMUSP00000107819
NCBI entrez gene - 21673     See in Manteia.
MGI - MGI:98659
RefSeq - NM_009345
RefSeq - NM_001043228
RefSeq Peptide - NP_001036693
RefSeq Peptide - NP_033371
swissprot - P09838
swissprot - Q3UZ80
Ensembl - ENSMUSG00000025014
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnttENSDARG00000104792Danio rerio
 DNTTENSGALG00000006983Gallus gallus
 DNTTENSG00000107447Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Polm / Q9JIW4 / polymerase (DNA directed), mu / Q9NP87* / DNA polymerase mu*ENSMUSG0000002047440
Poll / Q9QXE2 / polymerase (DNA directed), lambda / Q9UGP5* / DNA polymerase lambda*ENSMUSG0000002521824
Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*ENSMUSG0000003153615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR001726  DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu
 IPR002054  DNA-directed DNA polymerase X
 IPR010996  DNA polymerase beta-like, N-terminal domain
 IPR018944  DNA polymerase lambda, fingers domain
 IPR019843  DNA polymerase family X, binding site
 IPR022312  DNA polymerase family X
 IPR027292  DNA nucleotidylexotransferase (TdT)
 IPR027421  DNA polymerase lambda lyase domain superfamily
 IPR028207  DNA polymerase beta, palm domain
 IPR029398  DNA polymerase beta, thumb domain
 IPR036420  BRCT domain superfamily
 IPR037160  DNA polymerase, thumb domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006259 DNA metabolic process ISO
 biological_processGO:0006304 DNA modification IEA
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0000791 euchromatin IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016363 nuclear matrix IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0003912 DNA nucleotidylexotransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0034061 DNA polymerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csn3tm1Kuma/Csn3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003726 decreased autoantibody level "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0008761 abnormal immunoglobulin light chain V-J recombination "any anomaly in the process by which V and J gene segments of the immunoglobulin light chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dntttm1Gfn/Dntttm1Gfn,Polmtm1Crey/Polmtm1Crey
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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