ENSGALG00000011492


Gallus gallus

Features
Gene ID: ENSGALG00000011492
  
Biological name :XRCC5
  
Synonyms : X-ray repair cross complementing 5 / XRCC5
  
Possible biological names infered from orthology : P13010 / P27641 / X-ray repair complementing defective repair in Chinese hamster cells 5
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 23625446
Gene end: 23667655
  
Corresponding Affymetrix probe sets: Gga.11729.1.S1_s_at (Chicken Array)   Gga.3214.1.S1_at (Chicken Array)   GgaAffx.23575.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018706
NCBI entrez gene - 424222     See in Manteia.
RefSeq - XM_015290041
RefSeq - XM_422072
swissprot - F1NZI1
Ensembl - ENSGALG00000011492
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xrcc5ENSDARG00000099298Danio rerio
 XRCC5ENSG00000079246Homo sapiens
 Xrcc5ENSMUSG00000026187Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR005160  Ku70/Ku80 C-terminal arm
 IPR005161  Ku70/Ku80, N-terminal alpha/beta
 IPR006164  Ku70/Ku80 beta-barrel domain
 IPR014893  Ku, C-terminal
 IPR016194  SPOC-like, C-terminal domain superfamily
 IPR024193  Ku80


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IBA
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050769 positive regulation of neurogenesis IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:1904430 negative regulation of t-circle formation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0043564 Ku70:Ku80 complex IEA
 cellular_componentGO:0070419 nonhomologous end joining complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003691 double-stranded telomeric DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016817 hydrolase activity, acting on acid anhydrides IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042162 telomeric DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051575 5"-deoxyribose-5-phosphate lyase activity IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007753 POLL / DNA polymerase lambda / Q9QXE2* / Q9UGP5* / polymerase (DNA directed), lambda*  / reaction
 ENSGALG00000016854 LIG4 / DNA ligase 4 / P49917* / Q8BTF7* / ligase IV, DNA, ATP-dependent*  / reaction
 ENSGALG00000011492 XRCC5 / X-ray repair cross complementing 5 / P13010* / P27641* / X-ray repair complementing defective repair in Chinese hamster cells 5*  / complex
 ENSGALG00000015620 XRCC4 / X-ray repair cross complementing 4 / Q13426* / X-ray repair complementing defective repair in Chinese hamster cells 4*  / reaction






 

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