ENSGALG00000016854


Gallus gallus

Features
Gene ID: ENSGALG00000016854
  
Biological name :LIG4
  
Synonyms : DNA ligase 4 / LIG4
  
Possible biological names infered from orthology : ligase IV, DNA, ATP-dependent / P49917 / Q8BTF7
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 140176223
Gene end: 140179854
  
Corresponding Affymetrix probe sets: GgaAffx.12164.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000027179
NCBI entrez gene - 418764     See in Manteia.
RefSeq - NM_001030816
RefSeq - XM_015274177
RefSeq Peptide - NP_001025987
swissprot - F1P275
Ensembl - ENSGALG00000016854
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lig4ENSDARG00000060620Danio rerio
 LIG4ENSG00000174405Homo sapiens
 Lig4ENSMUSG00000049717Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000977  DNA ligase, ATP-dependent
 IPR001357  BRCT domain
 IPR012308  DNA ligase, ATP-dependent, N-terminal
 IPR012309  DNA ligase, ATP-dependent, C-terminal
 IPR012310  DNA ligase, ATP-dependent, central
 IPR012340  Nucleic acid-binding, OB-fold
 IPR016059  DNA ligase, ATP-dependent, conserved site
 IPR021536  DNA ligase IV domain
 IPR029710  DNA ligase 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000012 single strand break repair IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0002328 pro-B cell differentiation IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006266 DNA ligation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0033151 V(D)J recombination IEA
 biological_processGO:0033152 immunoglobulin V(D)J recombination IEA
 biological_processGO:0033153 T cell receptor V(D)J recombination IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045190 isotype switching IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0050769 positive regulation of neurogenesis IEA
 biological_processGO:0051102 DNA ligation involved in DNA recombination IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair IEA
 biological_processGO:0051276 chromosome organization IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0097680 double-strand break repair via classical nonhomologous end joining IEA
 biological_processGO:2001252 positive regulation of chromosome organization IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex IEA
 cellular_componentGO:0032807 DNA ligase IV complex IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0070419 nonhomologous end joining complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003909 DNA ligase activity IEA
 molecular_functionGO:0003910 DNA ligase (ATP) activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007753 POLL / DNA polymerase lambda / Q9QXE2* / Q9UGP5* / polymerase (DNA directed), lambda*  / reaction
 ENSGALG00000011492 XRCC5 / X-ray repair cross complementing 5 / P13010* / P27641* / X-ray repair complementing defective repair in Chinese hamster cells 5*  / reaction
 ENSGALG00000015620 XRCC4 / X-ray repair cross complementing 4 / Q13426* / X-ray repair complementing defective repair in Chinese hamster cells 4*  / complex






 

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