ENSDARG00000060620


Danio rerio

Features
Gene ID: ENSDARG00000060620
  
Biological name :lig4
  
Synonyms : lig4 / ligase IV, DNA, ATP-dependent
  
Possible biological names infered from orthology : DNA ligase 4 / P49917 / Q8BTF7
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 29267841
Gene end: 29271473
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000080083
NCBI entrez gene - 569525     See in Manteia.
RefSeq - NM_001103123
RefSeq - XM_005159958
RefSeq Peptide - NP_001096593
swissprot - F1Q9E8
ZFIN ID - ZDB-GENE-070820-10
Ensembl - ENSDARG00000060620
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LIG4ENSGALG00000016854Gallus gallus
 LIG4ENSG00000174405Homo sapiens
 Lig4ENSMUSG00000049717Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000977  DNA ligase, ATP-dependent
 IPR001357  BRCT domain
 IPR012308  DNA ligase, ATP-dependent, N-terminal
 IPR012309  DNA ligase, ATP-dependent, C-terminal
 IPR012310  DNA ligase, ATP-dependent, central
 IPR012340  Nucleic acid-binding, OB-fold
 IPR016059  DNA ligase, ATP-dependent, conserved site
 IPR021536  DNA ligase IV domain
 IPR029710  DNA ligase 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling IBA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IMP
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0033152 immunoglobulin V(D)J recombination IBA
 biological_processGO:0051103 DNA ligation involved in DNA repair IBA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex IBA
 cellular_componentGO:0032807 DNA ligase IV complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003909 DNA ligase activity IEA
 molecular_functionGO:0003910 DNA ligase (ATP) activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000075083 prkdc / protein kinase, DNA-activated, catalytic polypeptide / P78527* / P97313* / DNA-dependent protein kinase catalytic subunit *  / reaction
 ENSDARG00000010732 xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / complex
 ENSDARG00000045704 Q5RGE5 / dclre1c / DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) / Q96SD1* / Q8K4J0* / Protein artemis * / DNA cross-link repair 1C*  / reaction
 ENSDARG00000071551 xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / reaction
 ENSDARG00000099298 xrcc5 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / reaction






 

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