ENSGALG00000042469


Gallus gallus

Features
Gene ID: ENSGALG00000042469
  
Biological name :PRKDC
  
Synonyms : DNA-dependent protein kinase catalytic subunit / PRKDC
  
Possible biological names infered from orthology : P78527 / P97313 / protein kinase, DNA-activated, catalytic polypeptide
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 108253971
Gene end: 108338935
  
Corresponding Affymetrix probe sets: Gga.189.1.S1_at (Chicken Array)   Gga.189.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000051478
Ensembl peptide - ENSGALP00000059070
Ensembl peptide - ENSGALP00000052176
NCBI entrez gene - 395376     See in Manteia.
RefSeq - NM_204658
RefSeq Peptide - NP_989989
swissprot - A0A1L1RK07
swissprot - A0A1D5PH99
swissprot - A0A1D5PFB5
Ensembl - ENSGALG00000042469
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkdcENSDARG00000075083Danio rerio
 PRKDCENSG00000253729Homo sapiens
 PrkdcENSMUSG00000022672Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATR / ATR serine/threonine kinase / Q13535*ENSGALG0000000266311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR003151  PIK-related kinase, FAT
 IPR003152  FATC domain
 IPR011009  Protein kinase-like domain superfamily
 IPR012582  NUC194
 IPR014009  PIK-related kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002326 B cell lineage commitment IEA
 biological_processGO:0002328 pro-B cell differentiation IEA
 biological_processGO:0002360 T cell lineage commitment IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0016233 telomere capping IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030098 lymphocyte differentiation IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0033151 V(D)J recombination IEA
 biological_processGO:0033152 immunoglobulin V(D)J recombination IEA
 biological_processGO:0033153 T cell receptor V(D)J recombination IEA
 biological_processGO:0035234 ectopic germ cell programmed cell death IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 biological_processGO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0070419 nonhomologous end joining complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004677 DNA-dependent protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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