ENSGALG00000005028


Gallus gallus

Features
Gene ID: ENSGALG00000005028
  
Biological name :TOP3A
  
Synonyms : DNA topoisomerase 3-alpha isoform 1 / TOP3A
  
Possible biological names infered from orthology : DNA topoisomerase III alpha / O70157 / Q13472 / topoisomerase (DNA) III alpha
  
Species: Gallus gallus
  
Chr. number: 14
Strand: -1
Band:
Gene start: 5109957
Gene end: 5121859
  
Corresponding Affymetrix probe sets: Gga.11401.1.S1_a_at (Chicken Array)   Gga.11401.2.S1_at (Chicken Array)   Gga.12028.1.S1_a_at (Chicken Array)   GgaAffx.26384.1.S1_at (Chicken Array)   GgaAffx.3133.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043544
Ensembl peptide - ENSGALP00000046156
Ensembl peptide - ENSGALP00000058400
Ensembl peptide - ENSGALP00000008036
NCBI entrez gene - 416517     See in Manteia.
RefSeq - NM_001256490
RefSeq - NM_001256492
RefSeq - NM_001256491
RefSeq - NM_001030636
RefSeq Peptide - NP_001243421
RefSeq Peptide - NP_001025807
RefSeq Peptide - NP_001243419
RefSeq Peptide - NP_001243420
swissprot - A0A1D5NT91
swissprot - F1P1F3
swissprot - A0A1D5PZI7
swissprot - A0A1D5P0H8
Ensembl - ENSGALG00000005028
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top3aENSDARG00000052827Danio rerio
 TOP3AENSG00000177302Homo sapiens
 Top3aENSMUSG00000002814Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TOP3B / DNA topoisomerase III beta / O95985* / Q9Z321* / topoisomerase (DNA) III beta*ENSGALG0000003005125


Protein motifs (from Interpro)
Interpro ID Name
 IPR000380  DNA topoisomerase, type IA
 IPR003601  DNA topoisomerase, type IA, domain 2
 IPR003602  DNA topoisomerase, type IA, DNA-binding domain
 IPR006171  TOPRIM domain
 IPR010666  Zinc finger, GRF-type
 IPR013497  DNA topoisomerase, type IA, central
 IPR013498  DNA topoisomerase, type IA, zn finger
 IPR013824  DNA topoisomerase, type IA, central region, subdomain 1
 IPR013825  DNA topoisomerase, type IA, central region, subdomain 2
 IPR013826  DNA topoisomerase, type IA, central region, subdomain 3
 IPR023405  DNA topoisomerase, type IA, core domain
 IPR023406  DNA topoisomerase, type IA, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006265 DNA topological change IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / complex / reaction
 ENSGALG00000002663 ATR / ATR serine/threonine kinase / Q13535*  / complex / reaction
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / complex / reaction
 ENSGALG00000004037 DNA2 / Q5ZKG3 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / Q6ZQJ5* / DNA replication helicase...  / complex
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000007155 RMI2 / Q5ZM20 / RecQ-mediated genome instability protein 2 / Q96E14* / Q3UPE3* / RecQ mediated genome instability 2*  / complex
 ENSGALG00000005279 BRIP1 / Q3YK19 / Fanconi anemia group J protein homolog / Q5SXJ3* / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / complex / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / complex / reaction






 

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