ENSGALG00000009942


Gallus gallus

Features
Gene ID: ENSGALG00000009942
  
Biological name :MDM2
  
Synonyms : MDM2 / MDM2 proto-oncogene
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase Mdm2 / P23804 / Q00987
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 35298405
Gene end: 35309601
  
Corresponding Affymetrix probe sets: Gga.10726.1.S1_at (Chicken Array)   Gga.13422.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016144
NCBI entrez gene - 395609     See in Manteia.
RefSeq - XM_015277638
RefSeq - NM_001199384
RefSeq - XM_015277568
RefSeq - XM_015277612
RefSeq - XM_015277522
RefSeq Peptide - NP_001186313
swissprot - F1NGX6
Ensembl - ENSGALG00000009942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mdm2ENSDARG00000033443Danio rerio
 MDM2ENSG00000135679Homo sapiens
 Mdm2ENSMUSG00000020184Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MDM4 / MDM4, p53 regulator / O15151* / O35618* / transformed mouse 3T3 cell double minute 4*ENSGALG0000000063613


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR001876  Zinc finger, RanBP2-type
 IPR003121  SWIB/MDM2 domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015459  Ubiquitin-protein ligase E3 MDM2
 IPR016495  p53 negative regulator Mdm2/Mdm4
 IPR028340  E3 ubiquitin-protein ligase Mdm2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0003170 heart valve development IEA
 biological_processGO:0003181 atrioventricular valve morphogenesis IEA
 biological_processGO:0003203 endocardial cushion morphogenesis IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0003283 atrial septum development IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
 biological_processGO:0007089 traversing start control point of mitotic cell cycle IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0018205 peptidyl-lysine modification IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0042176 regulation of protein catabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0045184 establishment of protein localization IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0060411 cardiac septum morphogenesis IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0072717 cellular response to actinomycin D IEA
 biological_processGO:1901797 negative regulation of signal transduction by p53 class mediator IEA
 biological_processGO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:1990000 amyloid fibril formation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008097 5S rRNA binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:0061663 NEDD8 ligase activity IEA
 molecular_functionGO:0097110 scaffold protein binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the cytosol
SUMOylation of ubiquitinylation proteins
Ub-specific processing proteases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Stabilization of p53
Regulation of RUNX3 expression and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003085 CDK1 / cyclin-dependent kinase 1 / P06493* / P11440*  / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000005695 CHEK2 / checkpoint kinase 2 / O96017* / Q9Z265* / Serine/threonine-protein kinase Chk2 *  / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction
 ENSGALG00000009942 MDM2 / MDM2 proto-oncogene / P23804* / Q00987* / E3 ubiquitin-protein ligase Mdm2 *  / reaction / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000001718 CCNG1 / cyclin G1 / P51945* / P51959*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000026137 CDKN2B / Q8N726* / P42772* / P55271* / CDKN2A* / P42771* / cyclin dependent kinase inhibitor 2A* / cyclin dependent kinase inhibitor 2B* / Cyclin-dependent kinase 4 inhibitor B *  / complex
 ENSGALG00000007307 USP7 / ubiquitin specific peptidase 7 / Q93009*  / complex
 ENSGALG00000013971 SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr