ENSGALG00000007307


Gallus gallus

Features
Gene ID: ENSGALG00000007307
  
Biological name :USP7
  
Synonyms : ubiquitin specific peptidase 7 / USP7
  
Possible biological names infered from orthology : Q93009
  
Species: Gallus gallus
  
Chr. number: 14
Strand: 1
Band:
Gene start: 9970094
Gene end: 10034004
  
Corresponding Affymetrix probe sets: Gga.9341.1.S1_at (Chicken Array)   Gga.9341.1.S2_at (Chicken Array)   Gga.9341.2.S1_at (Chicken Array)   Gga.9341.3.S1_at (Chicken Array)   Gga.9341.3.S1_a_at (Chicken Array)   Gga.9341.4.A1_at (Chicken Array)   Gga.9341.4.S1_at (Chicken Array)   Gga.9341.4.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054732
Ensembl peptide - ENSGALP00000039011
NCBI entrez gene - 395126     See in Manteia.
RefSeq - NM_204471
RefSeq Peptide - NP_989802
swissprot - F1P4U4
swissprot - A0A1D5PPD3
Ensembl - ENSGALG00000007307
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp7ENSDARG00000073710Danio rerio
 USP7ENSG00000187555Homo sapiens
 Usp7ENSMUSG00000022710Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP34 / ubiquitin carboxyl-terminal hydrolase 34 / Q6ZQ93* / Q70CQ2* / ubiquitin specific peptidase 34*ENSGALG0000000445517
ENSGALG0000001623617
USP47 / ubiquitin specific peptidase 47 / Q8BY87* / Q96K76*ENSGALG0000000556917
USP40 / ubiquitin specific peptidase 40 / Q8BWR4* / Q9NVE5*ENSGALG0000000422816
USP24 / ubiquitin specific peptidase 24 / B1AY13* / Q9UPU5*ENSGALG0000001080515
USP48 / ubiquitin carboxyl-terminal hydrolase 48 / Q3V0C5* / Q86UV5* / ubiquitin specific peptidase 48*ENSGALG0000003085713
USP41* / USP18* / Q9WTV6* / Q3LFD5* / Q9UMW8* / ubiquitin specific peptidase 18* / ubiquitin specific peptidase 41*ENSGALG000000130577


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR018200  Ubiquitin specific protease, conserved site
 IPR024729  Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain
 IPR028889  Ubiquitin specific protease domain
 IPR029346  Ubiquitin carboxyl-terminal hydrolase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0010216 maintenance of DNA methylation IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0035520 monoubiquitinated protein deubiquitination IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IEA
 biological_processGO:1901537 positive regulation of DNA demethylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Regulation of PTEN localization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000009942 MDM2 / MDM2 proto-oncogene / P23804* / Q00987* / E3 ubiquitin-protein ligase Mdm2 *  / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction






 

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