ENSDARG00000073710


Danio rerio

Features
Gene ID: ENSDARG00000073710
  
Biological name :usp7
  
Synonyms : ubiquitin specific peptidase 7 (herpes virus-associated) / usp7
  
Possible biological names infered from orthology : Q93009 / ubiquitin specific peptidase 7
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 27606505
Gene end: 27642128
  
Corresponding Affymetrix probe sets: Dr.17905.1.S1_at (Zebrafish Array)   Dr.22279.1.A1_at (Zebrafish Array)   XM_686123_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000125968
Ensembl peptide - ENSDARP00000002502
NCBI entrez gene - 553758     See in Manteia.
RefSeq - XM_005163957
RefSeq - XM_686123
swissprot - I3ISS5
swissprot - F1QUS9
ZFIN ID - ZDB-GENE-030131-3656
Ensembl - ENSDARG00000073710
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP7ENSGALG00000007307Gallus gallus
 USP7ENSG00000187555Homo sapiens
 Usp7ENSMUSG00000022710Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
usp47 / ubiquitin specific peptidase 47 / Q96K76*ENSDARG0000010264517
usp9 / ubiquitin specific peptidase 9ENSDARG0000001370817
USP34 / ubiquitin specific peptidase 34 / Q70CQ2*ENSDARG0000010225215
usp40 / ubiquitin specific peptidase 40 / Q8BWR4* / Q9NVE5*ENSDARG0000007119715
usp48 / ubiquitin specific peptidase 48 / Q3V0C5* / Q86UV5*ENSDARG0000009030113
si:ch211-212k18.13ENSDARG000001056148
usp18 / ubiquitin specific peptidase 18 / USP41* / Q9WTV6* / Q9UMW8* / Q3LFD5* / ubiquitin specific peptidase 41*ENSDARG000000880786
usp24 / ubiquitin specific peptidase 24ENSDARG000000599253


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR018200  Ubiquitin specific protease, conserved site
 IPR024729  Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain
 IPR028889  Ubiquitin specific protease domain
 IPR029346  Ubiquitin carboxyl-terminal hydrolase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:1904888 cranial skeletal system development IMP
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Regulation of PTEN localization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0001058 caudal fin caudal fin deformed , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , abnormal
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 ZFA:0001604 caudal fin upper lobe caudal fin upper lobe fused with caudal fin lower lobe , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000041435 uba52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSDARG00000032725 rps27a / ribosomal protein S27a / P62979* / P62983* / AL136454.1*  / reaction
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction
 ENSDARG00000033443 mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase / P23804* / Q00987* / MDM2 proto-oncogene* / E3 ubiquitin-protein ligase Mdm2 *  / complex / reaction
 ENSDARG00000000729 daxx / death-domain associated protein / Q9UER7* / Mus musculus Fas death domain-associated protein (Daxx), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000100916 uvssa / E7EXT2 / UV-stimulated scaffold protein A / Q8N1N5* / Q2YD98* / Q9D479*  / complex






 

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