ENSMUSG00000022710


Mus musculus

Features
Gene ID: ENSMUSG00000022710
  
Biological name :Usp7
  
Synonyms : ubiquitin specific peptidase 7 / Usp7
  
Possible biological names infered from orthology : Q93009
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 8689595
Gene end: 8792308
  
Corresponding Affymetrix probe sets: 10437594 (MoGene1.0st)   1419920_s_at (Mouse Genome 430 2.0 Array)   1419921_s_at (Mouse Genome 430 2.0 Array)   1434371_x_at (Mouse Genome 430 2.0 Array)   1437118_at (Mouse Genome 430 2.0 Array)   1438249_at (Mouse Genome 430 2.0 Array)   1454948_at (Mouse Genome 430 2.0 Array)   1454949_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133398
Ensembl peptide - ENSMUSP00000124093
Ensembl peptide - ENSMUSP00000124382
Ensembl peptide - ENSMUSP00000124576
NCBI entrez gene - 252870     See in Manteia.
MGI - MGI:2182061
RefSeq - XM_006522141
RefSeq - NM_001003918
RefSeq - XM_006522138
RefSeq - XM_006522139
RefSeq Peptide - NP_001003918
swissprot - E0CY04
swissprot - F8VPX1
swissprot - G3UWR8
swissprot - E9PXY8
Ensembl - ENSMUSG00000022710
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp7ENSDARG00000073710Danio rerio
 USP7ENSGALG00000007307Gallus gallus
 USP7ENSG00000187555Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp9x / ubiquitin specific peptidase 9, X chromosome / Q93008* / ubiquitin specific peptidase 9, X-linked*ENSMUSG0000003101017
Usp34 / Q6ZQ93 / ubiquitin specific peptidase 34 / Q70CQ2*ENSMUSG0000005634217
Usp40 / Q8BWR4 / ubiquitin specific peptidase 40 / Q9NVE5*ENSMUSG0000000550117
Usp47 / Q8BY87 / ubiquitin specific peptidase 47 / Q96K76*ENSMUSG0000005926317
Usp9y / ubiquitin specific peptidase 9, Y chromosome / O00507* / ubiquitin specific peptidase 9, Y-linked*ENSMUSG0000006904416
Usp24 / B1AY13 / ubiquitin specific peptidase 24 / Q9UPU5*ENSMUSG0000002851415
Usp48 / Q3V0C5 / ubiquitin specific peptidase 48 / Q86UV5*ENSMUSG0000004341114
Usp18 / Q9WTV6 / ubiquitin specific peptidase 18 / USP41* / Q9UMW8* / Q3LFD5* / ubiquitin specific peptidase 41*ENSMUSG000000301077


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR018200  Ubiquitin specific protease, conserved site
 IPR024729  Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain
 IPR028889  Ubiquitin specific protease domain
 IPR029346  Ubiquitin carboxyl-terminal hydrolase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0010216 maintenance of DNA methylation IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0035520 monoubiquitinated protein deubiquitination IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:1901537 positive regulation of DNA demethylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Regulation of PTEN localization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Pde8atm1Dgen/Pde8atm1Dgen,Pde8btm1Dgen/Pde8btm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Pde8atm1Dgen/Pde8atm1Dgen,Pde8btm1Dgen/Pde8btm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
Show

Allelic Composition: Pde8atm1Dgen/Pde8atm1Dgen,Pde8btm1Dgen/Pde8btm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000850 absent cerebellum "missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pde8atm1Dgen/Pde8atm1Dgen,Pde8btm1Dgen/Pde8btm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Usp7tm2Wgu/Usp7tm2Wgu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Usp7tm2Wgu/Usp7tm2Wgu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pde8atm1Dgen/Pde8atm1Dgen,Pde8btm1Dgen/Pde8btm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008536 enlarged third ventricle "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pde8atm1Dgen/Pde8atm1Dgen,Pde8btm1Dgen/Pde8btm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Pde8atm1Dgen/Pde8atm1Dgen,Pde8btm1Dgen/Pde8btm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pde8atm1Dgen/Pde8atm1Dgen,Pde8btm1Dgen/Pde8btm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pde8atm1Dgen/Pde8atm1Dgen,Pde8btm1Dgen/Pde8btm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Usp7tm2Wgu/Usp7tm2Wgu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Usp7tm2Wgu/Usp7tm2Wgu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0011198 absent proamniotic cavity "absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Pde8atm1Dgen/Pde8atm1Dgen,Pde8btm1Dgen/Pde8btm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002307 Daxx / Mus musculus Fas death domain-associated protein (Daxx), transcript variant 3, mRNA. / Q9UER7* / death domain associated protein*  / complex / reaction
 ENSMUSG00000037355 Uvssa / Q9D479 / UV stimulated scaffold protein A / Q2YD98* / Q8N1N5*  / complex
 ENSMUSG00000068240 P62984 / Gm11808 / predicted gene 11808 / UBA52* / P62987* / ubiquitin A-52 residue ribosomal protein fusion product 1*  / reaction
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / complex / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000013663 Pten / O08586 / phosphatase and tensin homolog / P60484*  / reaction
 ENSMUSG00000020460 P62983 / Rps27a / ribosomal protein S27A / P62979*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr