ENSMUSG00000002307


Mus musculus

Features
Gene ID: ENSMUSG00000002307
  
Biological name :Daxx
  
Synonyms : Daxx / Mus musculus Fas death domain-associated protein (Daxx), transcript variant 3, mRNA.
  
Possible biological names infered from orthology : death domain associated protein / Q9UER7
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 33909414
Gene end: 33915589
  
Corresponding Affymetrix probe sets: 10444056 (MoGene1.0st)   1419026_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133303
Ensembl peptide - ENSMUSP00000078390
Ensembl peptide - ENSMUSP00000128504
Ensembl peptide - ENSMUSP00000134158
Ensembl peptide - ENSMUSP00000133319
Ensembl peptide - ENSMUSP00000133552
NCBI entrez gene - 13163     See in Manteia.
MGI - MGI:1197015
RefSeq - XM_006523580
RefSeq - XM_006523582
RefSeq - XM_006523581
RefSeq - NM_001199733
RefSeq - NM_001355704
RefSeq - NM_007829
RefSeq Peptide - NP_001186662
RefSeq Peptide - NP_001342633
RefSeq Peptide - NP_031855
swissprot - Q3UKR0
swissprot - G3UWJ9
swissprot - G3UWI4
swissprot - G3UX50
Ensembl - ENSMUSG00000002307
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 daxxENSDARG00000000729Danio rerio
 DAXXENSG00000204209Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005012  Daxx protein
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR031333  Daxx, N-terminal Rassf1C-interacting domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030521 androgen receptor signaling pathway IEA
 biological_processGO:0031396 regulation of protein ubiquitination IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0034620 cellular response to unfolded protein IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0072738 cellular response to diamide IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1903936 cellular response to sodium arsenite IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0070603 SWI/SNF superfamily-type complex IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0032183 SUMO binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0050681 androgen receptor binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/Gt(ROSA)26Sortm1(SNCA*A53T)Djmo
Genetic Background: involves: 129 * C57BL/6J

 MP:0003708 binucleate "two nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
Show

Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

 MP:0003891 increased allantois apoptosis "increase in the number of cells of the allantois undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Daxxtm1Maul/Daxxtm1Maul
Genetic Background: involves: 129/Sv

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0013181 absent placenta "absence of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin" [MGI:anna]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000022710 Usp7 / ubiquitin specific peptidase 7 / Q93009*  / complex / reaction






 

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