ENSMUSG00000059263


Mus musculus

Features
Gene ID: ENSMUSG00000059263
  
Biological name :Usp47
  
Synonyms : Q8BY87 / ubiquitin specific peptidase 47 / Usp47
  
Possible biological names infered from orthology : Q96K76
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F1
Gene start: 112023504
Gene end: 112111661
  
Corresponding Affymetrix probe sets: 10556350 (MoGene1.0st)   1426976_at (Mouse Genome 430 2.0 Array)   1426977_at (Mouse Genome 430 2.0 Array)   1457454_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102264
Ensembl peptide - ENSMUSP00000147619
Ensembl peptide - ENSMUSP00000151051
NCBI entrez gene - 74996     See in Manteia.
MGI - MGI:1922246
RefSeq - XM_006508274
RefSeq - NM_133758
RefSeq - NM_177249
RefSeq - XM_006508273
RefSeq Peptide - NP_598519
RefSeq Peptide - NP_796223
RefSeq Peptide - NP_001344881
swissprot - Q8BY87
swissprot - A0A1L1SV73
Ensembl - ENSMUSG00000059263
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp47ENSDARG00000102645Danio rerio
 USP47ENSGALG00000005569Gallus gallus
 USP47ENSG00000170242Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp40 / Q8BWR4 / ubiquitin specific peptidase 40 / Q9NVE5*ENSMUSG0000000550119
Usp34 / Q6ZQ93 / ubiquitin specific peptidase 34 / Q70CQ2*ENSMUSG0000005634215
Usp7 / ubiquitin specific peptidase 7 / Q93009*ENSMUSG0000002271014
Usp9x / ubiquitin specific peptidase 9, X chromosome / Q93008* / ubiquitin specific peptidase 9, X-linked*ENSMUSG0000003101013
Usp9y / ubiquitin specific peptidase 9, Y chromosome / O00507* / ubiquitin specific peptidase 9, Y-linked*ENSMUSG0000006904413
Usp48 / Q3V0C5 / ubiquitin specific peptidase 48 / Q86UV5*ENSMUSG0000004341113
Usp24 / B1AY13 / ubiquitin specific peptidase 24 / Q9UPU5*ENSMUSG0000002851412
Usp18 / Q9WTV6 / ubiquitin specific peptidase 18 / USP41* / Q9UMW8* / Q3LFD5* / ubiquitin specific peptidase 41*ENSMUSG000000301077


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle ISS
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0034644 cellular response to UV IMP
 biological_processGO:0035520 monoubiquitinated protein deubiquitination IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0071987 WD40-repeat domain binding IEA
 molecular_functionGO:0101005 ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Pknox1tm1Fbla/Pknox1tm1Fbla,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031536 Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*  / complex






 

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