ENSG00000170242


Homo sapiens

Features
Gene ID: ENSG00000170242
  
Biological name :USP47
  
Synonyms : Q96K76 / ubiquitin specific peptidase 47 / USP47
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.3
Gene start: 11841423
Gene end: 11959323
  
Corresponding Affymetrix probe sets: 221518_s_at (Human Genome U133 Plus 2.0 Array)   223117_s_at (Human Genome U133 Plus 2.0 Array)   223118_s_at (Human Genome U133 Plus 2.0 Array)   223119_s_at (Human Genome U133 Plus 2.0 Array)   223701_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000339957
Ensembl peptide - ENSP00000382382
Ensembl peptide - ENSP00000433146
NCBI entrez gene - 55031     See in Manteia.
OMIM - 614460
RefSeq - XM_017017954
RefSeq - NM_001282659
RefSeq - NM_001330208
RefSeq - NM_017944
RefSeq - XM_005252997
RefSeq - XM_011520196
RefSeq - XM_017017953
RefSeq Peptide - NP_001269588
RefSeq Peptide - NP_001317137
RefSeq Peptide - NP_060414
swissprot - Q96K76
Ensembl - ENSG00000170242
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp47ENSDARG00000102645Danio rerio
 USP47ENSGALG00000005569Gallus gallus
 Usp47ENSMUSG00000059263Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP40 / Q9NVE5 / ubiquitin specific peptidase 40ENSG0000008598220
USP34 / Q70CQ2 / ubiquitin specific peptidase 34ENSG0000011546415
USP7 / Q93009 / ubiquitin specific peptidase 7ENSG0000018755514
USP48 / Q86UV5 / ubiquitin specific peptidase 48ENSG0000009068613
USP9Y / O00507 / ubiquitin specific peptidase 9, Y-linkedENSG0000011437413
USP9X / Q93008 / ubiquitin specific peptidase 9, X-linkedENSG0000012448613
USP24 / Q9UPU5 / ubiquitin specific peptidase 24ENSG0000016240212
USP41 / Q3LFD5 / ubiquitin specific peptidase 41ENSG000001611337
USP18 / Q9UMW8 / ubiquitin specific peptidase 18ENSG000001849797


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035520 monoubiquitinated protein deubiquitination IDA
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0071987 WD40-repeat domain binding IPI
 molecular_functionGO:0101005 ubiquitinyl hydrolase activity IDA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000070501 POLB / P06746 / DNA polymerase beta  / complex






 

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