ENSG00000187555


Homo sapiens

Features
Gene ID: ENSG00000187555
  
Biological name :USP7
  
Synonyms : Q93009 / ubiquitin specific peptidase 7 / USP7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.2
Gene start: 8892094
Gene end: 8964514
  
Corresponding Affymetrix probe sets: 201498_at (Human Genome U133 Plus 2.0 Array)   201499_s_at (Human Genome U133 Plus 2.0 Array)   222032_s_at (Human Genome U133 Plus 2.0 Array)   230761_at (Human Genome U133 Plus 2.0 Array)   230967_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000459594
Ensembl peptide - ENSP00000457815
Ensembl peptide - ENSP00000458027
Ensembl peptide - ENSP00000343535
Ensembl peptide - ENSP00000371310
Ensembl peptide - ENSP00000439272
Ensembl peptide - ENSP00000454362
Ensembl peptide - ENSP00000454795
Ensembl peptide - ENSP00000455719
Ensembl peptide - ENSP00000456150
Ensembl peptide - ENSP00000456258
Ensembl peptide - ENSP00000457237
NCBI entrez gene - 7874     See in Manteia.
OMIM - 602519
RefSeq - XM_017023653
RefSeq - NM_001286457
RefSeq - NM_001286458
RefSeq - NM_001321858
RefSeq - NM_003470
RefSeq - XM_017023652
RefSeq Peptide - NP_003461
RefSeq Peptide - NP_001273386
RefSeq Peptide - NP_001273387
RefSeq Peptide - NP_001308787
swissprot - Q93009
swissprot - F5H2X1
swissprot - H3BMF6
swissprot - H3BND8
swissprot - H3BQD1
swissprot - H3BRA2
swissprot - H3BTM1
swissprot - H3BRI4
swissprot - H3BUV0
swissprot - H3BVA7
swissprot - I3L2D8
Ensembl - ENSG00000187555
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp7ENSDARG00000073710Danio rerio
 USP7ENSGALG00000007307Gallus gallus
 Usp7ENSMUSG00000022710Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP34 / Q70CQ2 / ubiquitin specific peptidase 34ENSG0000011546418
USP47 / Q96K76 / ubiquitin specific peptidase 47ENSG0000017024218
USP40 / Q9NVE5 / ubiquitin specific peptidase 40ENSG0000008598217
USP9X / Q93008 / ubiquitin specific peptidase 9, X-linkedENSG0000012448617
USP9Y / O00507 / ubiquitin specific peptidase 9, Y-linkedENSG0000011437416
USP24 / Q9UPU5 / ubiquitin specific peptidase 24ENSG0000016240215
USP48 / Q86UV5 / ubiquitin specific peptidase 48ENSG0000009068614
USP41 / Q3LFD5 / ubiquitin specific peptidase 41ENSG000001611337
USP18 / Q9UMW8 / ubiquitin specific peptidase 18ENSG000001849797


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR018200  Ubiquitin specific protease, conserved site
 IPR024729  Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain
 IPR028889  Ubiquitin specific protease domain
 IPR029346  Ubiquitin carboxyl-terminal hydrolase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010216 maintenance of DNA methylation IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0035520 monoubiquitinated protein deubiquitination IDA
 biological_processGO:0035616 histone H2B conserved C-terminal lysine deubiquitination ISS
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:1901537 positive regulation of DNA demethylation IDA
 biological_processGO:1904353 regulation of telomere capping TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body HDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0002039 p53 binding IDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IMP
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity IDA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Regulation of PTEN localization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000204209 DAXX / Q9UER7 / death domain associated protein  / complex / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000171862 PTEN / P60484 / phosphatase and tensin homolog  / reaction
 ENSG00000163945 UVSSA / Q2YD98 / Q8N1N5 / UV stimulated scaffold protein A  / complex
 ENSG00000135679 MDM2 / Q00987 / MDM2 proto-oncogene  / complex / reaction
 ENSG00000143947 P62979 / RPS27A / ribosomal protein S27a  / reaction
 ENSG00000221983 UBA52 / P62987 / ubiquitin A-52 residue ribosomal protein fusion product 1  / reaction






 

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