ENSG00000090686


Homo sapiens

Features
Gene ID: ENSG00000090686
  
Biological name :USP48
  
Synonyms : Q86UV5 / ubiquitin specific peptidase 48 / USP48
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.12
Gene start: 21678298
Gene end: 21783606
  
Corresponding Affymetrix probe sets: 220078_at (Human Genome U133 Plus 2.0 Array)   220079_s_at (Human Genome U133 Plus 2.0 Array)   225925_s_at (Human Genome U133 Plus 2.0 Array)   229812_at (Human Genome U133 Plus 2.0 Array)   232621_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000406256
Ensembl peptide - ENSP00000383157
Ensembl peptide - ENSP00000431832
Ensembl peptide - ENSP00000435612
Ensembl peptide - ENSP00000435604
Ensembl peptide - ENSP00000434073
Ensembl peptide - ENSP00000431949
Ensembl peptide - ENSP00000309262
Ensembl peptide - ENSP00000363862
Ensembl peptide - ENSP00000363864
NCBI entrez gene - 84196     See in Manteia.
OMIM - 617445
RefSeq - XM_017002497
RefSeq - NM_001350168
RefSeq - NM_032236
RefSeq - XM_005246009
RefSeq - XM_006710951
RefSeq - XM_006710955
RefSeq - XM_011542262
RefSeq - XM_011542263
RefSeq - XM_011542264
RefSeq - XM_011542265
RefSeq - XM_011542267
RefSeq - XM_011542268
RefSeq - XM_017002495
RefSeq - XM_017002496
RefSeq - NM_001032730
RefSeq - NM_001330394
RefSeq - NM_001350166
RefSeq - NM_001350167
RefSeq Peptide - NP_001317323
RefSeq Peptide - NP_001337095
RefSeq Peptide - NP_001337096
RefSeq Peptide - NP_001337097
RefSeq Peptide - NP_115612
RefSeq Peptide - NP_001027902
swissprot - Q86UV5
swissprot - A0A0A0MRS6
swissprot - E9PJH5
swissprot - E9PJ93
swissprot - E9PJ87
swissprot - H3BLX5
swissprot - E9PRY5
Ensembl - ENSG00000090686
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp48ENSDARG00000090301Danio rerio
 USP48ENSGALG00000030857Gallus gallus
 Usp48ENSMUSG00000043411Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP47 / Q96K76 / ubiquitin specific peptidase 47ENSG0000017024218
USP34 / Q70CQ2 / ubiquitin specific peptidase 34ENSG0000011546418
USP9X / Q93008 / ubiquitin specific peptidase 9, X-linkedENSG0000012448617
USP40 / Q9NVE5 / ubiquitin specific peptidase 40ENSG0000008598216
USP9Y / O00507 / ubiquitin specific peptidase 9, Y-linkedENSG0000011437416
USP24 / Q9UPU5 / ubiquitin specific peptidase 24ENSG0000016240216
USP7 / Q93009 / ubiquitin specific peptidase 7ENSG0000018755515
USP18 / Q9UMW8 / ubiquitin specific peptidase 18ENSG000001849798
USP41 / Q3LFD5 / ubiquitin specific peptidase 41ENSG000001611338


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR006615  Peptidase C19, ubiquitin-specific peptidase, DUSP domain
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR033841  Ubiquitin-specific peptidase 48
 IPR035927  DUSP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex






 

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