ENSG00000115464


Homo sapiens

Features
Gene ID: ENSG00000115464
  
Biological name :USP34
  
Synonyms : Q70CQ2 / ubiquitin specific peptidase 34 / USP34
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p15
Gene start: 61187463
Gene end: 61470769
  
Corresponding Affymetrix probe sets: 207365_x_at (Human Genome U133 Plus 2.0 Array)   212065_s_at (Human Genome U133 Plus 2.0 Array)   212066_s_at (Human Genome U133 Plus 2.0 Array)   215013_s_at (Human Genome U133 Plus 2.0 Array)   233595_at (Human Genome U133 Plus 2.0 Array)   242647_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398960
Ensembl peptide - ENSP00000410559
Ensembl peptide - ENSP00000381577
Ensembl peptide - ENSP00000388129
Ensembl peptide - ENSP00000398489
NCBI entrez gene - 9736     See in Manteia.
OMIM - 615295
RefSeq - NM_014709
RefSeq Peptide - NP_055524
swissprot - H7C150
swissprot - A0A0C4DG73
swissprot - Q70CQ2
swissprot - H7C183
swissprot - H7BZ73
Ensembl - ENSG00000115464
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP34ENSDARG00000102252Danio rerio
 USP34ENSGALG00000004455Gallus gallus
 Usp34ENSMUSG00000056342Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP9X / Q93008 / ubiquitin specific peptidase 9, X-linkedENSG0000012448615
USP9Y / O00507 / ubiquitin specific peptidase 9, Y-linkedENSG0000011437415
USP24 / Q9UPU5 / ubiquitin specific peptidase 24ENSG0000016240215
USP47 / Q96K76 / ubiquitin specific peptidase 47ENSG000001702426
USP40 / Q9NVE5 / ubiquitin specific peptidase 40ENSG000000859825
USP48 / Q86UV5 / ubiquitin specific peptidase 48ENSG000000906865
USP7 / Q93009 / ubiquitin specific peptidase 7ENSG000001875555
USP41 / Q3LFD5 / ubiquitin specific peptidase 41ENSG000001611332
USP18 / Q9UMW8 / ubiquitin specific peptidase 18ENSG000001849792


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0071108 protein K48-linked deubiquitination IDA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IMP
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173273 TNKS / O95271 / tankyrase  / reaction
 ENSG00000103126 AXIN1 / O15169  / reaction
 ENSG00000107854 TNKS2 / Q9H2K2 / tankyrase 2  / reaction
 ENSG00000118518 Q9NTX7 / RNF146 / ring finger protein 146  / reaction
 ENSG00000168646 AXIN2 / Q9Y2T1  / reaction






 

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