ENSG00000118518


Homo sapiens

Features
Gene ID: ENSG00000118518
  
Biological name :RNF146
  
Synonyms : Q9NTX7 / ring finger protein 146 / RNF146
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q22.33
Gene start: 127266610
Gene end: 127288567
  
Corresponding Affymetrix probe sets: 221430_s_at (Human Genome U133 Plus 2.0 Array)   223886_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477440
Ensembl peptide - ENSP00000477204
Ensembl peptide - ENSP00000479890
Ensembl peptide - ENSP00000309365
Ensembl peptide - ENSP00000349253
Ensembl peptide - ENSP00000357297
Ensembl peptide - ENSP00000476424
Ensembl peptide - ENSP00000476814
Ensembl peptide - ENSP00000476867
Ensembl peptide - ENSP00000476888
Ensembl peptide - ENSP00000477019
Ensembl peptide - ENSP00000477168
NCBI entrez gene - 81847     See in Manteia.
OMIM - 612137
RefSeq - XM_017011343
RefSeq - NM_001242844
RefSeq - NM_001242845
RefSeq - NM_001242846
RefSeq - NM_001242847
RefSeq - NM_001242848
RefSeq - NM_001242849
RefSeq - NM_001242850
RefSeq - NM_001242851
RefSeq - NM_001242852
RefSeq - NM_030963
RefSeq - XM_006715571
RefSeq - XM_011536161
RefSeq - XM_011536162
RefSeq - XM_011536163
RefSeq - XM_011536164
RefSeq - XM_017011336
RefSeq - XM_017011337
RefSeq - XM_017011338
RefSeq - XM_017011339
RefSeq - XM_017011340
RefSeq - XM_017011341
RefSeq - XM_017011342
RefSeq Peptide - NP_001229780
RefSeq Peptide - NP_001229781
RefSeq Peptide - NP_112225
RefSeq Peptide - NP_001229773
RefSeq Peptide - NP_001229774
RefSeq Peptide - NP_001229775
RefSeq Peptide - NP_001229776
RefSeq Peptide - NP_001229777
RefSeq Peptide - NP_001229778
RefSeq Peptide - NP_001229779
swissprot - V9GYK9
swissprot - V9GZ53
swissprot - A0A0G2JLL7
swissprot - Q9NTX7
swissprot - V9GYY4
Ensembl - ENSG00000118518
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf146ENSDARG00000089981Danio rerio
 RNF146ENSGALG00000026820Gallus gallus
 Q9CZW6ENSMUSG00000038876Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004170  WWE domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018123  WWE domain, subgroup
 IPR033509  E3 ubiquitin-protein ligase RNF146
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0070936 protein K48-linked ubiquitination IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS
 molecular_functionGO:0072572 poly-ADP-D-ribose binding IDA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Degradation of AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103126 AXIN1 / O15169  / reaction / complex
 ENSG00000173273 TNKS / O95271 / tankyrase  / complex / reaction
 ENSG00000107854 TNKS2 / Q9H2K2 / tankyrase 2  / complex / reaction
 ENSG00000168646 AXIN2 / Q9Y2T1  / complex / reaction
 ENSG00000115464 USP34 / Q70CQ2 / ubiquitin specific peptidase 34  / reaction






 

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contact: otassy@igbmc.fr