ENSMUSG00000038876


Mus musculus

Features
Gene ID: ENSMUSG00000038876
  
Biological name :Rnf146
  
Synonyms : Q9CZW6 / ring finger protein 146 / Rnf146
  
Possible biological names infered from orthology : Q9NTX7
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A4
Gene start: 29344176
Gene end: 29362442
  
Corresponding Affymetrix probe sets: 10368486 (MoGene1.0st)   10368490 (MoGene1.0st)   1417733_at (Mouse Genome 430 2.0 Array)   1425001_at (Mouse Genome 430 2.0 Array)   1425713_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149976
Ensembl peptide - ENSMUSP00000124772
Ensembl peptide - ENSMUSP00000124814
Ensembl peptide - ENSMUSP00000037224
Ensembl peptide - ENSMUSP00000124215
Ensembl peptide - ENSMUSP00000124288
NCBI entrez gene - 68031     See in Manteia.
MGI - MGI:1915281
RefSeq - NM_001110196
RefSeq - NM_001110197
RefSeq - NM_001110198
RefSeq - NM_001284279
RefSeq - NM_026518
RefSeq Peptide - NP_080794
RefSeq Peptide - NP_001103667
RefSeq Peptide - NP_001103668
RefSeq Peptide - NP_001271208
RefSeq Peptide - NP_001103666
swissprot - Q9CZW6
swissprot - H9KV17
swissprot - A0A1L1SSN4
Ensembl - ENSMUSG00000038876
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf146ENSDARG00000089981Danio rerio
 RNF146ENSGALG00000026820Gallus gallus
 Q9NTX7ENSG00000118518Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004170  WWE domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018123  WWE domain, subgroup
 IPR033509  E3 ubiquitin-protein ligase RNF146
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:0072572 poly-ADP-D-ribose binding ISO


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Degradation of AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Arhgap29em1(IMPC)J/Arhgap29+
Genetic Background: C57BL/6NJ-Arhgap29em1(IMPC)J/J

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0000085 large anterior fontanelle "enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Arhgap29em1(IMPC)J/Arhgap29+
Genetic Background: C57BL/6NJ-Arhgap29em1(IMPC)J/J

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap29em1(IMPC)J/Arhgap29+
Genetic Background: C57BL/6NJ-Arhgap29em1(IMPC)J/J

 MP:0004189 abnormal alveolar process "any structural anomaly of the thickened ridge of bone in the mandible and maxilla that holds the tooth sockets" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0004337 clavicle hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0008273 abnormal intramembranous bone ossification "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0010965 decreased compact bone volume 
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0011504 abnormal limb long bone morphology 
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0011711 decreased osteoblast differentiation 
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0011922 abnormal circulating osteocalcin level "aberrant concentration in the blood of this hormone secreted by osteoblasts which are found in bone and dentin" [MPD:Molly]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0030009 increased bone marrow adipose tissue amount "increased quantity of the bone marrow fat-storing cells/tissue" [PMID:27094502]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0030387 large posterior fontanelle "an abnormally increased size of the triangle-shaped membranous interval between the pair of parietal bones and the occipital bone for age-related norms; the posterior fontanelle is located at the lambda, at the junction between the sagittal suture and the lambdoid suture" [MGI:anna]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0030439 decreased osteoblast proliferation "reduction in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

 MP:0030471 abnormal ameloblast differentiation "any anomaly in the process in which a relatively unspecialized cell acquires specialized features of a functional ameloblast, a tall, columnar, polarized epithelial cell in the innermost layer of the enamel organ of a developing tooth involved with the formation of enamel matrix" [GO:0036305, PMID:19090561]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6J * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031529 Tnks / Q6PFX9 / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase / O95271* / tankyrase*  / complex / reaction
 ENSMUSG00000024811 Tnks2 / Q3UES3 / Tankyrase-2 / Q9H2K2*  / complex / reaction
 ENSMUSG00000024182 Axin1 / O15169*  / complex / reaction
 ENSMUSG00000000142 Axin2 / O88566 / Q9Y2T1*  / complex / reaction
 ENSMUSG00000056342 Usp34 / Q6ZQ93 / ubiquitin specific peptidase 34 / Q70CQ2*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr