ENSMUSG00000031529


Mus musculus

Features
Gene ID: ENSMUSG00000031529
  
Biological name :Tnks
  
Synonyms : Q6PFX9 / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase / Tnks
  
Possible biological names infered from orthology : O95271 / tankyrase
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A4
Gene start: 34826460
Gene end: 34965690
  
Corresponding Affymetrix probe sets: 10578157 (MoGene1.0st)   1432630_at (Mouse Genome 430 2.0 Array)   1433778_at (Mouse Genome 430 2.0 Array)   1445358_at (Mouse Genome 430 2.0 Array)   1459910_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033929
Ensembl peptide - ENSMUSP00000147555
Ensembl peptide - ENSMUSP00000147527
NCBI entrez gene - 21951     See in Manteia.
MGI - MGI:1341087
RefSeq - NM_175091
RefSeq Peptide - NP_780300
swissprot - A0A1B0GRK1
swissprot - A0A1B0GRH5
swissprot - Q6PFX9
Ensembl - ENSMUSG00000031529
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnksaENSDARG00000077650Danio rerio
 tnksbENSDARG00000062897Danio rerio
 TNKSENSGALG00000043164Gallus gallus
 TNKSENSG00000173273Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnks2 / Q3UES3 / Tankyrase-2 / Q9H2K2*ENSMUSG0000002481172
Ank2 / Q8C8R3 / Ankyrin-2 / Q01484*ENSMUSG0000003282625
Ank3 / G5E8K5 / Ankyrin-3 / Q12955*ENSMUSG0000006960124
Ank1 / Q02357 / Ankyrin-1 / P16157*ENSMUSG0000003154323
Q8BTI7 / Ankrd52 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C / Q8NB46* / ankyrin repeat domain 52*ENSMUSG0000001449819
B2RXR6 / Ankrd44 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B / Q8N8A2* / ankyrin repeat domain 44*ENSMUSG0000005233118
Q505D1 / Ankrd28 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A / O15084* / ankyrin repeat domain 28*ENSMUSG0000001449618
Invs / inversin isoform 2 / Q9Y283* / inversin*ENSMUSG0000002834412
Ankrd65 / ankyrin repeat domain 65 / E5RJM6*ENSMUSG000000784878


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR028731  Tankyrase-1
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051225 spindle assembly IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0070198 protein localization to chromosome, telomeric region IEA
 biological_processGO:0070212 protein poly-ADP-ribosylation IEA
 biological_processGO:0070213 protein auto-ADP-ribosylation IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening IEA
 biological_processGO:1904743 negative regulation of telomeric DNA binding IEA
 biological_processGO:1904908 negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0097431 mitotic spindle pole IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Degradation of AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001711 abnormal placenta 
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009303 decreased renal fat pad weight 
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tnkstm1.1Yjc/Tnks+,Tnks2tm1.1Yjc/Tnks2tm1.1Yjc
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0012134 absent umbilical cord "absence of or failure to form the connective stalk between the fetus and the placenta" [MGI:anna]
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0012301 absent umbilical cord blood vessels "absence of any of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton s jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place" [MGI:anna]
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024182 Axin1 / O15169*  / complex / reaction
 ENSMUSG00000000142 Axin2 / O88566 / Q9Y2T1*  / complex / reaction
 ENSMUSG00000013663 Pten / O08586 / phosphatase and tensin homolog / P60484*  / reaction
 ENSMUSG00000038876 Q9CZW6 / Rnf146 / ring finger protein 146 / Q9NTX7*  / complex / reaction
 ENSMUSG00000056342 Usp34 / Q6ZQ93 / ubiquitin specific peptidase 34 / Q70CQ2*  / reaction






 

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