ENSGALG00000043164


Gallus gallus

Features
Gene ID: ENSGALG00000043164
  
Biological name :TNKS
  
Synonyms : tankyrase-1 / TNKS
  
Possible biological names infered from orthology : O95271 / Q6PFX9 / tankyrase / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 49701547
Gene end: 49808051
  
Corresponding Affymetrix probe sets: Gga.8541.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047328
Ensembl peptide - ENSGALP00000056109
NCBI entrez gene - 374252     See in Manteia.
RefSeq - NM_204340
RefSeq Peptide - NP_989671
swissprot - A0A1D5PT67
swissprot - A0A1D5P3S3
Ensembl - ENSGALG00000043164
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnksaENSDARG00000077650Danio rerio
 tnksbENSDARG00000062897Danio rerio
 TNKSENSG00000173273Homo sapiens
 TnksENSMUSG00000031529Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNKS2 / tankyrase-2 / Q3UES3* / Q9H2K2*ENSGALG0000001461474
ANK3 / ankyrin 3 / G5E8K5* / Q12955*ENSGALG0000000313526
ANK2 / ankyrin 2 / Q01484* / Q8C8R3*ENSGALG0000001204425
ANK1 / ankyrin 1 / P16157* / Q02357*ENSGALG0000000359420
ANKRD52 / serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C / Q8BTI7* / Q8NB46* / ankyrin repeat domain 52*ENSGALG0000003197319
ANKRD28 / ankyrin repeat domain 28 / O15084* / Q505D1* / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A *ENSGALG0000001122619
Q5F478 / ANKRD44 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B / B2RXR6* / Q8N8A2* / ankyrin repeat domain 44*ENSGALG0000000799618
INVS / inversin / Q9Y283* / inversin isoform 2 *ENSGALG0000001344113
ENSGALG0000004324510


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR028731  Tankyrase-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051225 spindle assembly IEA
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0070198 protein localization to chromosome, telomeric region IEA
 biological_processGO:0070212 protein poly-ADP-ribosylation IEA
 biological_processGO:0070213 protein auto-ADP-ribosylation IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening IEA
 biological_processGO:1904743 negative regulation of telomeric DNA binding IEA
 biological_processGO:1904908 negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0097431 mitotic spindle pole IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0042393 histone binding IEA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Degradation of AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000026820 RNF146 / ring finger protein 146 / Q9CZW6* / Q9NTX7*  / complex / reaction
 ENSGALG00000029402 AXIN1 / O15169*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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