ENSGALG00000014614


Gallus gallus

Features
Gene ID: ENSGALG00000014614
  
Biological name :TNKS2
  
Synonyms : tankyrase-2 / TNKS2
  
Possible biological names infered from orthology : Q3UES3 / Q9H2K2
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 19890122
Gene end: 19915269
  
Corresponding Affymetrix probe sets: Gga.8537.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023517
NCBI entrez gene - 374253     See in Manteia.
RefSeq - NM_204341
RefSeq Peptide - NP_989672
swissprot - F1N8D6
Ensembl - ENSGALG00000014614
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNKS2ENSG00000107854Homo sapiens
 Tnks2ENSMUSG00000024811Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNKS / tankyrase-1 / O95271* / Q6PFX9* / tankyrase* / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase*ENSGALG0000004316481
ANK3 / ankyrin 3 / G5E8K5* / Q12955*ENSGALG0000000313528
ANK2 / ankyrin 2 / Q01484* / Q8C8R3*ENSGALG0000001204427
ANK1 / ankyrin 1 / P16157* / Q02357*ENSGALG0000000359421
ANKRD52 / serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C / Q8BTI7* / Q8NB46* / ankyrin repeat domain 52*ENSGALG0000003197321
ANKRD28 / ankyrin repeat domain 28 / O15084* / Q505D1* / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A *ENSGALG0000001122620
Q5F478 / ANKRD44 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B / B2RXR6* / Q8N8A2* / ankyrin repeat domain 44*ENSGALG0000000799619
INVS / inversin / Q9Y283* / inversin isoform 2 *ENSGALG0000001344113
ENSGALG0000004324511


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0070198 protein localization to chromosome, telomeric region IEA
 biological_processGO:0070213 protein auto-ADP-ribosylation IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening IEA
 cellular_componentGO:0000242 pericentriolar material IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0019899 enzyme binding IEA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Degradation of AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000026820 RNF146 / ring finger protein 146 / Q9CZW6* / Q9NTX7*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000029402 AXIN1 / O15169*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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