ENSMUSG00000000142


Mus musculus

Features
Gene ID: ENSMUSG00000000142
  
Biological name :Axin2
  
Synonyms : Axin2 / O88566
  
Possible biological names infered from orthology : Q9Y2T1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 108920349
Gene end: 108950783
  
Corresponding Affymetrix probe sets: 10382228 (MoGene1.0st)   1421341_at (Mouse Genome 430 2.0 Array)   1436845_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051331
Ensembl peptide - ENSMUSP00000120664
Ensembl peptide - ENSMUSP00000119915
Ensembl peptide - ENSMUSP00000116956
Ensembl peptide - ENSMUSP00000102322
NCBI entrez gene - 12006     See in Manteia.
MGI - MGI:1270862
RefSeq - XM_006532057
RefSeq - XM_006532060
RefSeq - XM_006532059
RefSeq - XM_006532058
RefSeq - NM_015732
RefSeq Peptide - NP_056547
swissprot - O88566
swissprot - A2ABR0
swissprot - A2ABQ7
swissprot - A2ABQ8
swissprot - A2ABQ9
Ensembl - ENSMUSG00000000142
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 axin2ENSDARG00000100149Danio rerio
 AXIN2ENSGALG00000039200Gallus gallus
 AXIN2ENSG00000168646Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Axin1 / O15169*ENSMUSG0000002418242


Protein motifs (from Interpro)
Interpro ID Name
 IPR001158  DIX domain
 IPR014936  Axin beta-catenin binding
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR029071  Ubiquitin-like domain superfamily
 IPR032101  Axin-1/2, tankyrase-binding domain
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001957 intramembranous ossification IMP
 biological_processGO:0003139 secondary heart field specification IGI
 biological_processGO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway IDA
 biological_processGO:0030282 bone mineralization IMP
 biological_processGO:0032423 regulation of mismatch repair IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043570 maintenance of DNA repeat elements IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0048255 mRNA stabilization IEA
 biological_processGO:0061181 regulation of chondrocyte development IMP
 biological_processGO:0070602 regulation of centromeric sister chromatid cohesion IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0070411 I-SMAD binding IPI


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Degradation of AXIN
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ClppGt(IST13563G11)Tigm/ClppGt(IST13563G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Pik3cbtm1.1Jdo/Pik3cbtm1.1Jdo
Genetic Background: involves: C57BL/6

Allelic Composition: Axin2M1J/Axin2+
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0000653 abnormal sex gland morphology "anomalous structure of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rspo1tm1Mcch/Rspo1tm1Mcch
Genetic Background: involves: 129 * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

Allelic Composition: Axin2em1Fstl/Axin2+
Genetic Background: involves: C57BL/6J * C57BL/6JIcoCrlLumc * CBA/J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

Allelic Composition: Axin2em1Fstl/Axin2+
Genetic Background: involves: C57BL/6J * C57BL/6JIcoCrlLumc * CBA/J

 MP:0003418 premature intramembranous bone ossification "early onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0006281 abnormal tail development "anomaly in the formation of the tail" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pik3cbtm1.1Jdo/Pik3cbtm1.1Jdo
Genetic Background: involves: C57BL/6

Allelic Composition: Axin2M1J/Axin2+
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0011710 increased osteoblast differentiation 
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0030367 premature metopic suture closure "early closure of the metopic suture of the skull; premature closure of this suture compromises the transverse growth of both the frontal bones and can cause a narrow, triangular shaped forehead (trigonocephaly) that is associated with orbital hypotelorism" [http://www.skullbaseinstitute.com/craniosynostosis-craniofacial/trigonocephaly.html, PMID:23960302]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0030370 absent jugum limitans "missing the bony ridge that, in rodents, runs paracoronally and divides the metopic (interfrontal) suture transversely into the anterior and posterior frontal sutures" [MGI:anna, PMID:15790973]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0030438 increased osteoblast proliferation "increase in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024811 Tnks2 / Q3UES3 / Tankyrase-2 / Q9H2K2*  / reaction / complex
 ENSMUSG00000031529 Tnks / Q6PFX9 / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase / O95271* / tankyrase*  / reaction / complex
 ENSMUSG00000038876 Q9CZW6 / Rnf146 / ring finger protein 146 / Q9NTX7*  / reaction / complex
 ENSMUSG00000018363 A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000056342 Usp34 / Q6ZQ93 / ubiquitin specific peptidase 34 / Q70CQ2*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr