ENSDARG00000100149


Danio rerio

Features
Gene ID: ENSDARG00000100149
  
Biological name :axin2
  
Synonyms : axin2 / axin 2 (conductin, axil) / P57095
  
Possible biological names infered from orthology : O88566 / Q9Y2T1
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 55627948
Gene end: 55650771
  
Corresponding Affymetrix probe sets: Dr.3727.1.S1_a_at (Zebrafish Array)   NM_131561_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000132477
Ensembl peptide - ENSDARP00000138141
Ensembl peptide - ENSDARP00000143690
NCBI entrez gene - 58080     See in Manteia.
RefSeq - NM_131561
RefSeq Peptide - NP_571636
swissprot - P57095
swissprot - Q502Q2
ZFIN ID - ZDB-GENE-000403-2
Ensembl - ENSDARG00000100149
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AXIN2ENSGALG00000039200Gallus gallus
 AXIN2ENSG00000168646Homo sapiens
 Axin2ENSMUSG00000000142Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
axin1 / O15169*ENSDARG0000010296442


Protein motifs (from Interpro)
Interpro ID Name
 IPR001158  DIX domain
 IPR014936  Axin beta-catenin binding
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR029071  Ubiquitin-like domain superfamily
 IPR032101  Axin-1/2, tankyrase-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001957 intramembranous ossification IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IDA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity IBA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Degradation of AXIN
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000038067 A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSDARG00000062897 tnksb / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b / TNKS* / Q6PFX9* / O95271* / tankyrase* / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase*  / complex / reaction
 ENSDARG00000077650 tnksa / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase a / TNKS* / Q6PFX9* / O95271* / tankyrase* / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase*  / complex / reaction
 ENSDARG00000089981 rnf146 / ring finger protein 146 / Q9CZW6* / Q9NTX7*  / complex / reaction






 

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