ENSMUSG00000069601


Mus musculus

Features
Gene ID: ENSMUSG00000069601
  
Biological name :Ank3
  
Synonyms : Ank3 / Ankyrin-3 / G5E8K5
  
Possible biological names infered from orthology : Q12955
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B5.3
Gene start: 69398773
Gene end: 70027438
  
Corresponding Affymetrix probe sets: 10363786 (MoGene1.0st)   1425202_a_at (Mouse Genome 430 2.0 Array)   1447259_at (Mouse Genome 430 2.0 Array)   1451628_a_at (Mouse Genome 430 2.0 Array)   1452124_at (Mouse Genome 430 2.0 Array)   1452872_at (Mouse Genome 430 2.0 Array)   1457288_at (Mouse Genome 430 2.0 Array)   1458894_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139496
Ensembl peptide - ENSMUSP00000138770
Ensembl peptide - ENSMUSP00000140724
Ensembl peptide - ENSMUSP00000151906
Ensembl peptide - ENSMUSP00000140773
Ensembl peptide - ENSMUSP00000045834
Ensembl peptide - ENSMUSP00000061698
Ensembl peptide - ENSMUSP00000090087
Ensembl peptide - ENSMUSP00000090088
Ensembl peptide - ENSMUSP00000090089
Ensembl peptide - ENSMUSP00000090090
Ensembl peptide - ENSMUSP00000138092
Ensembl peptide - ENSMUSP00000138095
Ensembl peptide - ENSMUSP00000138123
Ensembl peptide - ENSMUSP00000138285
Ensembl peptide - ENSMUSP00000138326
Ensembl peptide - ENSMUSP00000138337
Ensembl peptide - ENSMUSP00000138347
Ensembl peptide - ENSMUSP00000138348
Ensembl peptide - ENSMUSP00000138356
Ensembl peptide - ENSMUSP00000138375
Ensembl peptide - ENSMUSP00000138413
Ensembl peptide - ENSMUSP00000138450
Ensembl peptide - ENSMUSP00000138474
Ensembl peptide - ENSMUSP00000138481
Ensembl peptide - ENSMUSP00000138531
Ensembl peptide - ENSMUSP00000138586
Ensembl peptide - ENSMUSP00000138601
Ensembl peptide - ENSMUSP00000138603
Ensembl peptide - ENSMUSP00000138623
Ensembl peptide - ENSMUSP00000138671
Ensembl peptide - ENSMUSP00000138686
NCBI entrez gene - 11735     See in Manteia.
MGI - MGI:88026
RefSeq - XM_017313780
RefSeq - XM_006513135
RefSeq - XM_006513136
RefSeq - XM_006513137
RefSeq - XM_006513138
RefSeq - XM_006513139
RefSeq - XM_011243290
RefSeq - XM_011243291
RefSeq - XM_011243292
RefSeq - XM_011243293
RefSeq - XM_011243294
RefSeq - XM_011243295
RefSeq - XM_011243296
RefSeq - XM_011243297
RefSeq - XM_011243299
RefSeq - XM_011243300
RefSeq - XM_011243301
RefSeq - XM_011243303
RefSeq - XM_011243304
RefSeq - XM_011243305
RefSeq - XM_011243307
RefSeq - XM_011243308
RefSeq - XM_011243309
RefSeq - XM_011243310
RefSeq - XM_017313769
RefSeq - XM_017313770
RefSeq - XM_017313771
RefSeq - XM_017313772
RefSeq - XM_017313773
RefSeq - XM_017313774
RefSeq - XM_017313775
RefSeq - XM_017313776
RefSeq - XM_017313777
RefSeq - XM_017313778
RefSeq - XM_017313779
RefSeq - NM_009670
RefSeq - NM_146005
RefSeq - NM_170687
RefSeq - NM_170688
RefSeq - NM_170689
RefSeq - NM_170690
RefSeq - NM_170728
RefSeq - NM_170729
RefSeq - NM_170730
RefSeq - XM_006513122
RefSeq - XM_006513124
RefSeq - XM_006513125
RefSeq - XM_006513126
RefSeq - XM_006513127
RefSeq - XM_006513128
RefSeq - XM_006513129
RefSeq - XM_006513130
RefSeq - XM_006513133
RefSeq - XM_006513134
RefSeq Peptide - NP_033800
RefSeq Peptide - NP_666117
RefSeq Peptide - NP_733788
RefSeq Peptide - NP_733789
RefSeq Peptide - NP_733790
RefSeq Peptide - NP_733791
RefSeq Peptide - NP_733924
RefSeq Peptide - NP_733925
RefSeq Peptide - NP_733926
swissprot - S4R2C1
swissprot - S4R2F5
swissprot - S4R2J6
swissprot - S4R2K9
swissprot - S4R2S8
swissprot - W4VSQ0
swissprot - A0A087WNU5
swissprot - Q3UVY0
swissprot - S4R162
swissprot - S4R165
swissprot - S4R187
swissprot - S4R1S2
swissprot - S4R1U4
swissprot - S4R1X7
swissprot - S4R208
swissprot - A0A1W2P812
swissprot - S4R229
swissprot - A0A087WRU2
swissprot - G3X971
swissprot - G5E8K2
swissprot - G5E8K3
swissprot - G5E8K5
swissprot - A0A087WRP9
swissprot - S4R236
swissprot - S4R278
Ensembl - ENSMUSG00000069601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ank3aENSDARG00000061736Danio rerio
 ank3bENSDARG00000077582Danio rerio
 ANK3ENSGALG00000003135Gallus gallus
 ANK3ENSG00000151150Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ank2 / Q8C8R3 / Ankyrin-2 / Q01484*ENSMUSG0000003282657
Ank1 / Q02357 / Ankyrin-1 / P16157*ENSMUSG0000003154350
Tnks / Q6PFX9 / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase / O95271* / tankyrase*ENSMUSG0000003152916
Tnks2 / Q3UES3 / Tankyrase-2 / Q9H2K2*ENSMUSG0000002481116
Q505D1 / Ankrd28 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A / O15084* / ankyrin repeat domain 28*ENSMUSG0000001449614
Q8BTI7 / Ankrd52 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C / Q8NB46* / ankyrin repeat domain 52*ENSMUSG0000001449813
B2RXR6 / Ankrd44 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B / Q8N8A2* / ankyrin repeat domain 44*ENSMUSG0000005233113
Invs / inversin isoform 2 / Q9Y283* / inversin*ENSMUSG0000002834412
Ankrd65 / ankyrin repeat domain 65 / E5RJM6*ENSMUSG000000784877


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000906  ZU5 domain
 IPR002110  Ankyrin repeat
 IPR011029  Death-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis ISO
 biological_processGO:0007009 plasma membrane organization ISO
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007528 neuromuscular junction development ISS
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010650 positive regulation of cell communication by electrical coupling ISS
 biological_processGO:0010765 positive regulation of sodium ion transport ISS
 biological_processGO:0010960 magnesium ion homeostasis IMP
 biological_processGO:0019228 neuronal action potential IMP
 biological_processGO:0034112 positive regulation of homotypic cell-cell adhesion ISS
 biological_processGO:0043001 Golgi to plasma membrane protein transport ISO
 biological_processGO:0043266 regulation of potassium ion transport ISS
 biological_processGO:0045184 establishment of protein localization ISO
 biological_processGO:0045760 positive regulation of action potential TAS
 biological_processGO:0045838 positive regulation of membrane potential ISS
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0071286 cellular response to magnesium ion IMP
 biological_processGO:0071709 membrane assembly ISO
 biological_processGO:0072659 protein localization to plasma membrane ISS
 biological_processGO:0072660 maintenance of protein location in plasma membrane ISO
 biological_processGO:0090314 positive regulation of protein targeting to membrane ISS
 biological_processGO:0099612 protein localization to axon IMP
 biological_processGO:1900827 positive regulation of membrane depolarization during cardiac muscle cell action potential ISS
 biological_processGO:1902260 negative regulation of delayed rectifier potassium channel activity IMP
 biological_processGO:2000651 positive regulation of sodium ion transmembrane transporter activity ISS
 biological_processGO:2001259 positive regulation of cation channel activity ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005923 bicellular tight junction ISO
 cellular_componentGO:0009925 basal plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0014704 intercalated disc IDA
 cellular_componentGO:0014731 spectrin-associated cytoskeleton ISS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0016328 lateral plasma membrane ISO
 cellular_componentGO:0016529 sarcoplasmic reticulum ISS
 cellular_componentGO:0030018 Z disc ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030315 T-tubule ISS
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0031594 neuromuscular junction ISS
 cellular_componentGO:0033268 node of Ranvier IDA
 cellular_componentGO:0033270 paranode region of axon IDA
 cellular_componentGO:0042383 sarcolemma ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043034 costamere IBA
 cellular_componentGO:0043194 axon initial segment ISO
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane ISS
 molecular_functionGO:0005200 structural constituent of cytoskeleton ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding ISS
 molecular_functionGO:0030507 spectrin binding IBA
 molecular_functionGO:0030674 protein binding, bridging ISS
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0045296 cadherin binding ISS


Pathways (from Reactome)
Pathway description
Interaction between L1 and Ankyrins
COPI-mediated anterograde transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Bloc1s1tm1.1Wli/Bloc1s1tm1.1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bloc1s1tm1.1Wli/Bloc1s1tm1.1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bloc1s1tm1.1Wli/Bloc1s1tm1.1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bloc1s1tm1.1Wli/Bloc1s1tm1.1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bloc1s1tm1.1Wli/Bloc1s1tm1.1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bloc1s1tm1.1Wli/Bloc1s1tm1.1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bloc1s1tm1.1Wli/Bloc1s1tm1.1Wli
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Ank3tm2.1Bnt/Ank3tm2.1Bnt,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL/J

 MP:0009939 abnormal hippocampus neuron morphology 
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Allelic Composition: Bloc1s1tm1.1Wli/Bloc1s1tm1.1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0010732 abnormal node of Ranvier morphology "any structural anomaly of the short unmyelinated segments of an axon between myelinated segments, where voltage gated channels accumulate and regenerate an action potential as it is conducted along the axon" [PMID:18929652]
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Allelic Composition: Bloc1s1tm1.1Wli/Bloc1s1tm1.1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0010733 abnormal axon initial segment morphology "any structural anomaly of the short unmyelinated axon segment adjacent to the cell soma where voltage gated channels accumulate and axon potential initiation usually occurs" [PMID:18929652]
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Allelic Composition: Bloc1s1tm1.1Wli/Bloc1s1tm1.1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0010735 abnormal paranodal axoglial junction morphology "any structural anomaly of the structure in which the myelin sheath attaches to the axon at each end of each myelin segment; the axoglial junctions act as a diffusion barrier between the node and internode, maintaining domain-specific axolemmal membrane components" [PMID:19224642]
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Allelic Composition: Bloc1s1tm1.1Wli/Bloc1s1tm1.1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0010943 abnormal bronchus epithelium morphology "any structural anomaly of the epithelial layer of the bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk7tm1.1Ctr/Mapk7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mapk7tm1.1Ctr/Mapk7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mapk7tm1.1Ctr/Mapk7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011843 abnormal kidney collecting duct epithelium morphology "any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" [MGI:anna]
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Allelic Composition: Mapk7tm1.1Ctr/Mapk7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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