ENSMUSG00000031543


Mus musculus

Features
Gene ID: ENSMUSG00000031543
  
Biological name :Ank1
  
Synonyms : Ank1 / Ankyrin-1 / Q02357
  
Possible biological names infered from orthology : P16157
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 22974844
Gene end: 23150497
  
Corresponding Affymetrix probe sets: 10570894 (MoGene1.0st)   1419421_at (Mouse Genome 430 2.0 Array)   1425677_a_at (Mouse Genome 430 2.0 Array)   1443291_at (Mouse Genome 430 2.0 Array)   1452512_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116533
Ensembl peptide - ENSMUSP00000113656
Ensembl peptide - ENSMUSP00000117966
Ensembl peptide - ENSMUSP00000133901
Ensembl peptide - ENSMUSP00000133668
Ensembl peptide - ENSMUSP00000133322
Ensembl peptide - ENSMUSP00000121785
Ensembl peptide - ENSMUSP00000033947
Ensembl peptide - ENSMUSP00000081051
Ensembl peptide - ENSMUSP00000106316
Ensembl peptide - ENSMUSP00000112850
Ensembl peptide - ENSMUSP00000112966
Ensembl peptide - ENSMUSP00000113495
Ensembl peptide - ENSMUSP00000113531
Ensembl peptide - ENSMUSP00000113571
NCBI entrez gene - 11733     See in Manteia.
MGI - MGI:88024
RefSeq - XM_006509004
RefSeq - NM_001277281
RefSeq - NM_001277284
RefSeq - NM_001277286
RefSeq - NM_001277289
RefSeq - NM_001310436
RefSeq - NM_001310437
RefSeq - NM_031158
RefSeq - XM_006508989
RefSeq - XM_006508990
RefSeq - XM_006508991
RefSeq - XM_006508992
RefSeq - XM_006508993
RefSeq - XM_006508994
RefSeq - XM_006508995
RefSeq - XM_006508996
RefSeq - XM_006508997
RefSeq - XM_006508998
RefSeq - XM_006508999
RefSeq - XM_006509000
RefSeq - XM_006509001
RefSeq - XM_006509002
RefSeq - XM_006509003
RefSeq - NM_001110783
RefSeq - NM_001277280
RefSeq Peptide - NP_001264210
RefSeq Peptide - NP_001264213
RefSeq Peptide - NP_001264215
RefSeq Peptide - NP_001264218
RefSeq Peptide - NP_001297365
RefSeq Peptide - NP_001297366
RefSeq Peptide - NP_112435
RefSeq Peptide - NP_001104253
RefSeq Peptide - NP_001264209
swissprot - B7ZW98
swissprot - A0A0R4J1N7
swissprot - E9QNT8
swissprot - Q02357
swissprot - Q0VGY9
swissprot - D6RJ51
swissprot - D3Z5M4
swissprot - D3YTV8
swissprot - F7D1P5
swissprot - G3UXF4
swissprot - G3UY11
swissprot - G5E8J2
swissprot - G8JL84
Ensembl - ENSMUSG00000031543
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ank1aENSDARG00000059093Danio rerio
 ank1bENSDARG00000074777Danio rerio
 ANK1ENSGALG00000003594Gallus gallus
 ANK1ENSG00000029534Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ank3 / G5E8K5 / Ankyrin-3 / Q12955*ENSMUSG0000006960152
Ank2 / Q8C8R3 / Ankyrin-2 / Q01484*ENSMUSG0000003282650
Tnks / Q6PFX9 / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase / O95271* / tankyrase*ENSMUSG0000003152916
Tnks2 / Q3UES3 / Tankyrase-2 / Q9H2K2*ENSMUSG0000002481115
Q505D1 / Ankrd28 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A / O15084* / ankyrin repeat domain 28*ENSMUSG0000001449615
Q8BTI7 / Ankrd52 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C / Q8NB46* / ankyrin repeat domain 52*ENSMUSG0000001449814
B2RXR6 / Ankrd44 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B / Q8N8A2* / ankyrin repeat domain 44*ENSMUSG0000005233114
Invs / inversin isoform 2 / Q9Y283* / inversin*ENSMUSG0000002834412
Ankrd65 / ankyrin repeat domain 65 / E5RJM6*ENSMUSG000000784877


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000906  ZU5 domain
 IPR002110  Ankyrin repeat
 IPR011029  Death-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006779 porphyrin-containing compound biosynthetic process IMP
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010638 positive regulation of organelle organization IEA
 biological_processGO:0015672 monovalent inorganic cation transport IMP
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0055072 iron ion homeostasis IMP
 biological_processGO:0072659 protein localization to plasma membrane ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0014731 spectrin-associated cytoskeleton ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030673 axolemma IEA
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 cellular_componentGO:0031430 M band IEA
 cellular_componentGO:0031672 A band IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008093 cytoskeletal adaptor activity ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0030507 spectrin binding ISO
 molecular_functionGO:0051117 ATPase binding ISO


Pathways (from Reactome)
Pathway description
Interaction between L1 and Ankyrins
Neurofascin interactions
COPI-mediated anterograde transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1ity16/Ank1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0000314 schistocytosis "the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1MRI23420/Ank1MRI23420
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ank1MRI23420/Ank1MRI23420
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1MRI23420/Ank1MRI23420
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo
Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1pale/Ank1pale
Genetic Background: C57BL/6J-Ank1pale/GrsrJ

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ank1RBC2/Ank1+
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1pale/Ank1pale
Genetic Background: C57BL/6J-Ank1pale/GrsrJ

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo
Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Allelic Composition: Ank1ity16/Ank1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-2J/Spta1sph-2J
Genetic Background: C3HeB/FeJ-Spta1sph-2J

Allelic Composition: Ank1nb/Ank1+
Genetic Background: involves: C57BL/6J * WB/Re

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1MRI23420/Ank1MRI23420
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(CDX2-cre*)189Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1M1Btlr/Ank1+
Genetic Background: C57BL/6J-Ank1m1Btlr

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0002594 low mean erythrocyte count "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-2J/Spta1sph-2J
Genetic Background: C3HeB/FeJ-Spta1sph-2J

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-2J/Spta1sph-2J
Genetic Background: C3HeB/FeJ-Spta1sph-2J

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-2J/Spta1sph-2J
Genetic Background: C3HeB/FeJ-Spta1sph-2J

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-2J/Spta1sph-2J
Genetic Background: C3HeB/FeJ-Spta1sph-2J

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-2J/Spta1sph-2J
Genetic Background: C3HeB/FeJ-Spta1sph-2J

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1MRI23420/Ank1MRI23420
Genetic Background: SJL/J-Ank1MRI23420

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Spta1sph-2J/Spta1sph-2J
Genetic Background: C3HeB/FeJ-Spta1sph-2J

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Spta1sph-2J/Spta1sph-2J
Genetic Background: C3HeB/FeJ-Spta1sph-2J

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1MRI23420/Ank1MRI23420
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Spta1sph-2J/Spta1sph-2J
Genetic Background: C3HeB/FeJ-Spta1sph-2J

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0002814 hyperchromasia "increased capacity of a cell to stain with dye; usually refers to staining of cell nuclei with hematoxylin" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

 MP:0002830 gallstones "caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo
Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo

 MP:0002872 polycythemia "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1ity16/Ank1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Allelic Composition: Ank1M1Btlr/Ank1+
Genetic Background: C57BL/6J-Ank1m1Btlr

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0003332 liver abscess "collection of purulent exudate within the liver as a result of infection by bacteria, protozoa, or other agents " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: involves: C57BL/6J * WB/Re

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ank1RBC2/Ank1+
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1M1Btlr/Ank1+
Genetic Background: C57BL/6J-Ank1m1Btlr

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0004088 abnormal sarcoplasmic reticulum morphology "any structural abnormality in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo
Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo

 MP:0004121 abnormal sarcolemma morphology "structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo
Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo

 MP:0004145 abnormal muscle electrophysiology "anomaly in the function of the musculature as it relates to electrical phenomena" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo
Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo
Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo

 MP:0004246 abnormal extensor digitorum longus morphology "any structural anomaly of penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo
Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1MRI23420/Ank1MRI23420
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-2J/Spta1sph-2J
Genetic Background: C3HeB/FeJ-Spta1sph-2J

Allelic Composition: Ank1nb/Ank1+
Genetic Background: involves: C57BL/6J * WB/Re

Allelic Composition: Ank1RBC2/Ank1+
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

 MP:0005096 erythroblastosis "presence of erythroblasts in great number in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Allelic Composition: Ank1M1Btlr/Ank1+
Genetic Background: C57BL/6J-Ank1m1Btlr

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1M1Btlr/Ank1+
Genetic Background: C57BL/6J-Ank1m1Btlr

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: involves: C57BL/6J * WB/Re

 MP:0005639 hemosiderosis "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: involves: C57BL/6J * WB/Re

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0008387 hypochromic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0008742 abnormal kidney iron level "anomaly in the amount of iron present in the kidney tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: involves: C57BL/6J * WB/Re

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: involves: C57BL/6J * WB/Re

Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Allelic Composition: Ank1ity16/Ank1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0008850 increased hemoglobin concentration distribution width "higher than normal standard deviation of the distribution of erythrocytes by their cellular (individual) hemoglobin concentrations; high HDW is indicative of some types of anemia/thalassemia" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0008956 decreased cellular hemoglobin content "decrease in the mean of the red blood cell hemoglobin concentration (RBC CH) histogram, which represents the distribution of red blood cells by the amount of hemoglobin present in each individual cell independent of cell volume" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0009411 abnormal skeletal muscle fiber triad morphology "any structural anomaly of the skeletal muscle fiber structure comprised of the transverse tubule and the two associated terminal cisternae; each fiber normally has thousands of triads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo
Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo

 MP:0009412 skeletal muscle fiber degeneration "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo
Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1RBC2/Ank1+
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Allelic Composition: Ank1ity16/Ank1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0010035 increased erythrocyte clearance "increased elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life" [GO:0034102, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

 MP:0010074 stomatocytosis "deformation of red blood cells to a cup-like shape, with swelling and with an elongated area of central pallor, instead of the normal biconcave shape" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: involves: C57BL/6J * WB/Re

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0010163 hemolysis "destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

Allelic Composition: Ank1M1Btlr/Ank1+
Genetic Background: C57BL/6J-Ank1m1Btlr

Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0010177 acanthocytosis "presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: involves: C57BL/6J * WB/Re

 MP:0010375 increased kidney iron level "increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Allelic Composition: Ank1ity16/Ank1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0010751 decreased susceptibility to parasitic infection induced morbidity/mortality "decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank1MRI23420/Ank1+
Genetic Background: SJL/J-Ank1MRI23420

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ank1pale/Ank1pale
Genetic Background: C57BL/6J-Ank1pale/GrsrJ

Allelic Composition: Ank1MRI23420/Ank1MRI23420
Genetic Background: SJL/J-Ank1MRI23420

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Ank1M1Wlst/Ank1M1Wlst
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ank1MRI23420/Ank1MRI23420
Genetic Background: SJL/J-Ank1MRI23420

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Ank1RBC2/Ank1RBC2
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ank1pale/Ank1pale
Genetic Background: C57BL/6J-Ank1pale/GrsrJ

Allelic Composition: Ank1MRI23420/Ank1MRI23420
Genetic Background: SJL/J-Ank1MRI23420

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

 MP:0011188 increased erythrocyte protoporphyrin level "an accumulation of the intermediates of heme biosynthesis in red blood cells" [MGI:csmith]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: involves: C57BL/6J * WB/Re

Allelic Composition: Ank1nb/Ank1+
Genetic Background: involves: C57BL/6J * WB/Re

 MP:0011285 increased circulating erythropoietin level "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Ank1ity16/Ank1ity16
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo
Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo

 MP:0020409 abnormal cardiac thrombosis "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]
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Allelic Composition: Ank1nb/Ank1nb
Genetic Background: (WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020315 Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*  / complex / reaction
 ENSMUSG00000067889 Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*  / complex / reaction
 ENSMUSG00000011751 Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*  / reaction / complex
 ENSMUSG00000026532 Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*  / reaction / complex
 ENSMUSG00000021061 Sptb / spectrin beta, erythrocytic / P11277*  / complex / reaction
 ENSMUSG00000026442 Nfasc / Q810U3 / Neurofascin / O94856*  / complex / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000057738 P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*  / complex / reaction
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex






 

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